VIP Peptide, 10 mg vial, laboratory reference material
RESEARCH PEPTIDE

VIP PEPTIDE | MOLECULAR & ANALYTICAL RESEARCH

Vasoactive Intestinal Peptide — VPAC Receptor Research Material
$49.00
Vasoactive intestinal peptide (VIP) is a linear 28-residue, C-terminally amidated neuropeptide supplied as a lyophilized laboratory reference material for VPAC-receptor research. Research use only. Not for human or veterinary use.
✓ Scientific Identity Established
⏳ Laboratory Testing In Progress
⏳ Batch Documentation Pending
✓ Research Use Only
✓ U.S. Fulfillment
In Laboratory Testing
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Primary Literature Peer-reviewed sources
Research Use Only Laboratory research materials

Scientific Specifications

Reference characteristics for laboratory research materials.

CAS Number
40077-57-4
Molecular Formula
C147H238N44O42S
Molecular Weight
3325.8
Research Classification
Research Use Only (RUO). Not for human or veterinary use.

SCIENTIFIC OVERVIEW

Scientific background and research classification for this laboratory reference material.

Vasoactive intestinal peptide (VIP) is a linear 28-residue, C-terminally amidated neuropeptide of the secretin/glucagon peptide family. The mature human, porcine, and rat sequence is conserved. VIP is studied in receptor pharmacology, neuroendocrine signaling, smooth-muscle physiology, epithelial secretion, circadian biology, and immune modulation. This material is supplied for laboratory research use only.

Primary Research Category
Neurocognitive Research
Material Type
Lyophilized Peptide
Intended Use
Laboratory Research
Research Categories
Receptor Pharmacology Neuroscience Immune Regulation

Mechanism of Action

Molecular interaction profile describing how this research material engages receptor systems and influences downstream biological signaling pathways.

VIP primarily acts at VPAC1 and VPAC2 receptors, class-B G-protein-coupled receptors that predominantly couple to Gs, stimulate adenylyl cyclase, and increase intracellular cAMP. Depending on receptor, cell type, concentration, and assay, downstream calcium, ERK/MAPK, Akt, and CREB pathways may also be observed. VIP has lower affinity at PAC1 than PACAP; native VIP and modified analogs are not interchangeable.

Primary Organ Systems
  • Central Nervous System
  • Gastrointestinal System
  • Immune System

Research Documentation

Laboratory documentation is presented when available for the selected product specification and current lot.

In Laboratory Testing
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Laboratory documentation for the current lot is being completed.

Scientific References
Peer-Reviewed Literature

Explore published literature, clinical investigations, and foundational scientific research.

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Laboratory Resources
Technical Guidance

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Companion Materials

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Research Center

Scientific literature, laboratory resources, and related materials curated to support research involving this research material.

Scientific References
Peer-Reviewed Literature

Explore curated publications from peer-reviewed journals including clinical investigations, mechanistic studies, and foundational scientific literature.

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Scientific Dossier
Deeper Technical Treatment

Comprehensive scientific documentation including literature review, mechanism, pharmacology, and study data for this research material.

Laboratory Resources
Technical Guidance

Storage guidance, handling information, analytical standards, research policies, and laboratory support documentation.

Research Library

Curated peer-reviewed literature selected to provide scientific context for this research material.

Mechanistic Study•Science• 1970

Polypeptide with Broad Biological Activity: Isolation from Small Intestine

Foundational isolation report identifying a 28-residue intestinal polypeptide with broad physiological activity.
Velora Research Insight
Included as scientific context at the stated evidence level; no finished-lot or therapeutic inference.
PubMed →DOI →
Review Article•Biomedicines• 2022

Signal Transduction by VIP and PACAP Receptors

Authoritative review of VPAC1, VPAC2, and PAC1 receptor activation, structure, and signaling.
Velora Research Insight
Included as scientific context at the stated evidence level; no finished-lot or therapeutic inference.
PubMed →DOI →
Mechanistic Study•Biochemistry• 2000

Identification of key residues for interaction of vasoactive intestinal peptide with human VPAC1 and VPAC2 receptors

Alanine-scanning and receptor assays identifying VIP residues important for VPAC1/VPAC2 interaction.
Velora Research Insight
Included as scientific context at the stated evidence level; no finished-lot or therapeutic inference.
PubMed →DOI →
Pharmacology Study•Peptides• 2006

VIP and PACAP receptor pharmacology: a comparison of intracellular signaling pathways

Comparison of VIP/PACAP receptor signaling through cAMP and calcium pathways in receptor-expressing cells.
Velora Research Insight
Included as scientific context at the stated evidence level; no finished-lot or therapeutic inference.
PubMed →DOI →