Thymosin Alpha-1 | Peptide Reference Material
RESEARCH PEPTIDE

Thymosin Alpha-1 | Peptide Reference Material

N-Acetylated Thymic Peptide — Research Peptide
$89.00
N-acetylated 28-amino-acid thymic peptide supplied as a lyophilized laboratory reference material for immune-signaling research. Research use only. Not for human or veterinary use.
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Primary Literature Peer-reviewed sources
Research Use Only Laboratory research materials

Scientific Specifications

Reference characteristics for laboratory research materials.

CAS Number
62304-98-7
Purity
≥98%
Molecular Formula
C129H215N33O55
Molecular Weight
3108.3
Appearance
White lyophilized powder
Storage
-20°C
Research Classification
Research Use Only (RUO). Not for human or veterinary use.

SCIENTIFIC OVERVIEW

Scientific background and research classification for this laboratory reference material.

Thymosin alpha-1 (Tα1; thymalfasin; CAS 62304-98-7) is a 28-amino-acid, N-terminally acetylated peptide (Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN, free C-terminal -OH) originally isolated from thymic tissue and sequenced by Goldstein and colleagues (1977). The N-terminal acetylation is an intrinsic feature of its molecular identity.

As a laboratory reference material, thymosin alpha-1 supports research into innate and adaptive immune signaling. This material is supplied for laboratory research use only. It is chemically and biologically distinct from thymosin beta-4 and the TB-500 fragment.

Primary Research Category
Immune Regulation
Material Type
Lyophilized Peptide
Intended Use
Laboratory Research
Research Categories
Immune Regulation Innate Immunity Adaptive Immunity

Mechanism of Action

Molecular interaction profile describing how this research material engages receptor systems and influences downstream biological signaling pathways.

In murine dendritic-cell models, thymosin alpha-1 has been reported to act through Toll-like-receptor signaling: it activated dendritic cells for antifungal Th1 resistance via TLR-dependent signaling (Romani et al., 2004). These are cell-model and animal-model observations of proximal immune signaling; downstream cytokine and transcription-factor changes reported in that literature are not asserted here as direct molecular targets.

Primary Organ Systems
  • Immune System

Research Documentation

Laboratory documentation is presented when available for the selected product specification and current lot.

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Independent laboratory verification for this batch:

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Scientific References
Peer-Reviewed Literature

Explore published literature, clinical investigations, and foundational scientific research.

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Laboratory Resources
Technical Guidance

Storage guidance, handling recommendations, analytical methods, and laboratory best practices.

Related Research
Companion Materials

Discover complementary research materials frequently studied alongside this compound.

Research Center

Scientific literature, laboratory resources, and related materials curated to support research involving this research material.

Scientific References
Peer-Reviewed Literature

Explore curated publications from peer-reviewed journals including clinical investigations, mechanistic studies, and foundational scientific literature.

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Scientific Dossier
Deeper Technical Treatment

Comprehensive scientific documentation including literature review, mechanism, pharmacology, and study data for this research material.

Laboratory Resources
Technical Guidance

Storage guidance, handling information, analytical standards, research policies, and laboratory support documentation.

Research Library

Curated peer-reviewed literature selected to provide scientific context for this research material.

Analytical Study•Proceedings of the National Academy of Sciences of the United States of America• 1977

Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide

Foundational isolation and amino-acid sequence analysis of thymosin alpha-1, defining the 28-residue N-acetylated thymic polypeptide.
Velora Research Insight
Identity/sequence provenance for the governed molecule. Originator/discovery report — labeled as the founding, non-independent source.
PubMed →DOI →
Mechanistic Study•Blood• 2004

Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling

Mechanistic study reporting that thymosin alpha-1 activates dendritic cells for antifungal Th1 resistance through Toll-like-receptor signaling in a murine model.
Velora Research Insight
Independent proximal-signaling anchor (dendritic cell / TLR). Model-specific mechanistic evidence, not a target-binding claim.
PubMed →DOI →
Clinical Trial•BMJ• 2025

The efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial

Multicentre, double-blind, randomized, placebo-controlled phase-3 trial evaluating thymosin alpha-1 in patients with sepsis.
Velora Research Insight
Independent primary clinical research context; cited as scientific context only, not as a therapeutic representation of this research material.
PubMed →DOI →
Meta-Analysis•Frontiers in Cellular and Infection Microbiology• 2025

Efficacy of thymosin α1 for sepsis: a systematic review and meta-analysis of randomized controlled trials

Independent systematic review and meta-analysis synthesizing randomized controlled trials of thymosin alpha-1 in sepsis.
Velora Research Insight
Independent evidence synthesis of the randomized-trial literature; consolidates the clinical research context without extending it beyond the trials analyzed.
PubMed →DOI →