SS-31 (Elamipretide) | Peptide Reference Material
RESEARCH PEPTIDE

SS-31 (Elamipretide) | Peptide Reference Material

Mitochondria-Targeting Tetrapeptide — Research Peptide
$39.00
Mitochondria-targeting tetrapeptide supplied as a lyophilized laboratory reference material for cardiolipin and bioenergetics research. Research use only. Not for human or veterinary use.
✓ Scientific Identity Established
⏳ Laboratory Testing In Progress
⏳ Batch Documentation Pending
✓ Research Use Only
✓ U.S. Fulfillment
In Laboratory Testing
Lot Verification Variant-specific documentation
Traceable Lots VBL lot identification
Primary Literature Peer-reviewed sources
Research Use Only Laboratory research materials

Scientific Specifications

Reference characteristics for laboratory research materials.

CAS Number
736992-21-5
Purity
≥98%
Molecular Formula
C32H49N9O5
Molecular Weight
639.8
Appearance
White lyophilized powder
Storage
-20°C
Research Classification
Research Use Only (RUO). Not for human or veterinary use.

SCIENTIFIC OVERVIEW

Scientific background and research classification for this laboratory reference material.

SS-31 (elamipretide; CAS 736992-21-5) is a synthetic, cell-permeable mitochondria-targeting tetrapeptide with the sequence D-Arg-Dmt-Lys-Phe-NH2, where Dmt denotes 2',6'-dimethyltyrosine. It belongs to the Szeto–Schiller (SS) family of aromatic-cationic peptides that concentrate at the inner mitochondrial membrane (Zhao et al., 2004).

As a laboratory reference material, SS-31 supports research into mitochondrial bioenergetics, cardiolipin biology, and oxidative-stress responses in cellular and preclinical models. This material is supplied for laboratory research use only.

Primary Research Category
Longevity & Cellular Health
Material Type
Lyophilized Peptide
Intended Use
Laboratory Research
Research Categories
Mitochondrial Biology Cellular Bioenergetics Oxidative Stress

Mechanism of Action

Molecular interaction profile describing how this research material engages receptor systems and influences downstream biological signaling pathways.

SS-31 associates selectively with cardiolipin in the inner mitochondrial membrane. Mechanistic work established that this interaction stabilizes the cytochrome c/cardiolipin complex and promotes electron transport, optimizing mitochondrial ATP synthesis (Birk et al., 2013; Birk et al., 2014). Its foundational characterization identified the SS peptides as cell-permeable antioxidants targeted to the inner mitochondrial membrane (Zhao et al., 2004).

Primary Organ Systems
  • Renal System
  • Musculoskeletal System

Research Documentation

Laboratory documentation is presented when available for the selected product specification and current lot.

In Laboratory Testing
Laboratory Documentation In Progress

Laboratory documentation for the current lot is being completed.

Scientific References
Peer-Reviewed Literature

Explore published literature, clinical investigations, and foundational scientific research.

View References →
Laboratory Resources
Technical Guidance

Storage guidance, handling recommendations, analytical methods, and laboratory best practices.

Related Research
Companion Materials

Discover complementary research materials frequently studied alongside this compound.

Research Center

Scientific literature, laboratory resources, and related materials curated to support research involving this research material.

Scientific References
Peer-Reviewed Literature

Explore curated publications from peer-reviewed journals including clinical investigations, mechanistic studies, and foundational scientific literature.

Browse References →
Scientific Dossier
Deeper Technical Treatment

Comprehensive scientific documentation including literature review, mechanism, pharmacology, and study data for this research material.

Laboratory Resources
Technical Guidance

Storage guidance, handling information, analytical standards, research policies, and laboratory support documentation.

Research Library

Curated peer-reviewed literature selected to provide scientific context for this research material.

Mechanistic Study•The Journal of Biological Chemistry• 2004

Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury

Foundational study characterizing the Szeto–Schiller cell-permeable peptide antioxidants (including the SS-31 series) targeted to the inner mitochondrial membrane, inhibiting mitochondrial swelling, oxidative cell death, and reperfusion injury.
Velora Research Insight
Identity and foundational-mechanism anchor for the SS-31 tetrapeptide class as an inner-mitochondrial-membrane-targeted compound.
PubMed →DOI →
Mechanistic Study•Journal of the American Society of Nephrology• 2013

The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin

Mechanistic study demonstrating that SS-31 interacts with cardiolipin to re-energize ischemic mitochondria, defining the cardiolipin-binding mechanism of the compound.
Velora Research Insight
Primary mechanistic anchor for the dossier: establishes the cardiolipin interaction as SS-31's defining mode of action.
PubMed →DOI →
Review Article•British Journal of Pharmacology• 2014

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

Review synthesizing the pharmacology of SS-31 as a first-in-class cardiolipin-protective compound and its role in restoring mitochondrial bioenergetics.
Velora Research Insight
Evidence synthesis consolidating the cardiolipin-protective research framework for SS-31.
PubMed →DOI →
Clinical Trial•Neurology• 2023

Efficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy: The MMPOWER-3 Randomized Clinical Trial

Randomized clinical trial (MMPOWER-3) evaluating elamipretide in individuals with primary mitochondrial myopathy.
Velora Research Insight
Primary clinical research context for the mitochondrial pharmacology of SS-31; cited as scientific context, not as a therapeutic representation of this material.
PubMed →DOI →