Selank Peptide | Neuroimmune Research
RESEARCH PEPTIDE

Selank Peptide | Neuroimmune Research

Synthetic Tuftsin-Derived Heptapeptide — Research Peptide
$49.00
Selank is a synthetic tuftsin-derived heptapeptide studied in preclinical neurobiology, including GABAergic signaling and stress-model gene-expression research. Research use only; not for human or veterinary use.
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Primary Literature Peer-reviewed sources
Research Use Only Laboratory research materials

Scientific Specifications

Reference characteristics for laboratory research materials.

CAS Number
129954-34-3
Purity
≥98%
Molecular Formula
C33H57N11O9
Molecular Weight
751.87
Appearance
White lyophilized powder
Storage
-20°C
Research Classification
Research Use Only (RUO). Not for human or veterinary use.

SCIENTIFIC OVERVIEW

Scientific background and research classification for this laboratory reference material.

The supplier COA for Selank lot P250924-A022 identifies a chemically synthesized peptide with sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, CAS 129954-34-3, formula C33H57N11O9, and reported molecular weight 751.89. Independent reference sources identify this sequence as a tuftsin-derived heptapeptide. The COA reports measured acetate content but does not declare a discrete acetate stoichiometry. Experimental work has investigated enzyme inhibition, gene-expression changes, BDNF-associated observations, and behavioral models; these findings are bounded by their studied systems and do not establish direct receptor pharmacology or human therapeutic effects for Velora material.

Primary Research Category
Neurocognitive Research
Material Type
Lyophilized Peptide
Intended Use
Laboratory Research
Research Categories
Neuroscience Cognitive Function Immune Regulation Cytokine Signaling

Mechanism of Action

Molecular interaction profile describing how this research material engages receptor systems and influences downstream biological signaling pathways.

Reports describe inhibition of enkephalin-degrading enzymes as a possible proximal biochemical mechanism and changes in BDNF expression in rat hippocampal models. Other studies report gene-expression changes in animal systems. These observations do not establish a direct GABA receptor interaction, a single causal pathway, or a human therapeutic mechanism.

Primary Organ Systems
  • Central Nervous System
  • Immune System

Research Documentation

Laboratory documentation is presented when available for the selected product specification and current lot.

Batch Verified
Independent Batch Verification

Independent laboratory verification for this batch:

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  • Net Peptide Content
  • Endotoxin Testing
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Scientific References
Peer-Reviewed Literature

Explore published literature, clinical investigations, and foundational scientific research.

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Laboratory Resources
Technical Guidance

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Related Research
Companion Materials

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Research Center

Scientific literature, laboratory resources, and related materials curated to support research involving this research material.

Scientific References
Peer-Reviewed Literature

Explore curated publications from peer-reviewed journals including clinical investigations, mechanistic studies, and foundational scientific literature.

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Scientific Dossier
Deeper Technical Treatment

Comprehensive scientific documentation including literature review, mechanism, pharmacology, and study data for this research material.

Laboratory Resources
Technical Guidance

Storage guidance, handling information, analytical standards, research policies, and laboratory support documentation.

Research Library

Curated peer-reviewed literature selected to provide scientific context for this research material.

Mechanistic Study•Bulletin of Experimental Biology and Medicine• 2001

The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic action

Foundational report that Selank inhibits enkephalin-degrading enzymes, proposed as a possible biochemical mechanism underlying its activity in models of anxiolytic-type behavior.
Velora Research Insight
Founding proximal biochemical mechanism (enkephalinase inhibition). Mental Health Research Center / Kost lineage. Basis for the reported molecular-target vocabulary limitation (enkephalinase not in governed vocabulary).
PubMed →DOI →
Review Article•Protein & Peptide Letters• 2018

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity

Review of the molecular aspects of the heptapeptide Selank's biological activity, synthesizing reported mechanisms and pharmacology.
Velora Research Insight
Molecular-mechanism synthesis of Selank. Institute of Molecular Genetics (IMG, Moscow) / Myasoedov consortium — shared lineage with VSE-PUB-000090; counted as one institutional lineage.
PubMed →DOI →
Preclinical Study•Doklady Biological Sciences• 2008

Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo

In vivo study reporting that intranasal Selank regulates brain-derived neurotrophic factor (BDNF) expression in the rat hippocampus.
Velora Research Insight
Preclinical BDNF-expression mechanism in vivo. IMG Moscow consortium (shared lineage with VSE-PUB-000089) — not an additional independent lineage.
PubMed →DOI →
Preclinical Study•Bulletin of Experimental Biology and Medicine• 2019

Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex

Preclinical study reporting that Selank, a peptide analogue of tuftsin, protected against ethanol-induced memory impairment in rats with associated regulation of BDNF content in the hippocampus and prefrontal cortex.
Velora Research Insight
Independent-institution preclinical replication of BDNF-linked effects (Zakusov Institute of Pharmacology, Kolik lineage) — distinct from the IMG consortium; reinforces the tuftsin-analog identity.
PubMed →DOI →