Kisspeptin-10 Peptide | Neuroendocrine Research
RESEARCH PEPTIDE

Kisspeptin-10 Peptide | Neuroendocrine Research

Kisspeptin-Receptor (KISS1R) Agonist Decapeptide — Research Peptide
$49.00
Kisspeptin-10, a C-terminally amidated decapeptide, supplied as a lyophilized laboratory reference material for KISS1R and neuroendocrine-signaling research. Research use only. Not for human or veterinary use.
✓ Scientific Identity Established
⏳ Laboratory Testing In Progress
⏳ Batch Documentation Pending
✓ Research Use Only
✓ U.S. Fulfillment
In Laboratory Testing
Lot Verification Variant-specific documentation
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Primary Literature Peer-reviewed sources
Research Use Only Laboratory research materials

Scientific Specifications

Reference characteristics for laboratory research materials.

CAS Number
374675-21-5
Purity
≥98%
Molecular Formula
C63H83N17O14
Molecular Weight
1302.44
Appearance
White lyophilized powder
Storage
-20°C
Research Classification
Research Use Only (RUO). Not for human or veterinary use.

SCIENTIFIC OVERVIEW

Scientific background and research classification for this laboratory reference material.

Kisspeptin-10 (KP-10) is the C-terminal decapeptide of kisspeptin/metastin, sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (YNWNSFGLRF-NH2) with a C-terminal amide, corresponding to metastin(45-54). CAS 374675-21-5. It is supplied as a lyophilized peptide reference material for laboratory research use only.

As a research material, KP-10 is studied as an agonist ligand of the kisspeptin receptor (KISS1R, also known as GPR54) in neuroendocrine and receptor-pharmacology research. It is a distinct molecular entity from longer kisspeptin/metastin forms (e.g., kisspeptin-54, KP-13, KP-14).

Material Type
Lyophilized Peptide
Intended Use
Laboratory Research
Research Categories
Endocrine Research Hormonal Regulation Receptor Pharmacology Receptor Binding

Mechanism of Action

Molecular interaction profile describing how this research material engages receptor systems and influences downstream biological signaling pathways.

KP-10 is reported to act as an agonist at the kisspeptin receptor KISS1R (GPR54). In receptor and cell models this agonism has been characterized pharmacologically (Chen et al., 2025; Wang et al., 2021), and in whole-organism physiology kisspeptin signaling modulates the hypothalamic-pituitary-gonadal axis. These are receptor- and systems-level observations; the KISS1R receptor is described as the reported target but is not represented in the governed molecular-target vocabulary, and downstream gonadotropins are not asserted here as direct molecular targets.

Primary Organ Systems
  • Central Nervous System
  • Endocrine System

Research Documentation

Laboratory documentation is presented when available for the selected product specification and current lot.

In Laboratory Testing
Laboratory Documentation In Progress

Laboratory documentation for the current lot is being completed.

Scientific References
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Research Center

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Research Library

Curated peer-reviewed literature selected to provide scientific context for this research material.

Review Article•International Journal of Molecular Sciences• 2025

Kisspeptin Receptor Agonists and Antagonists: Strategies for Discovery and Implications for Human Health and Disease

Review of kisspeptin-receptor (KISS1R) agonist and antagonist discovery strategies and their pharmacology, providing receptor-pharmacology context for kisspeptin ligands including KP-10.
Velora Research Insight
Independent KISS1R receptor-pharmacology synthesis (Shaw/Xia). Receptor-level context, not a direct KP-10 target-binding assertion.
PubMed →DOI →
Mechanistic Study•Pharmacological Research• 2021

KP-10/Gpr54 attenuates rheumatic arthritis through inactivating NF-κB and MAPK signaling in macrophages

Mechanistic study reporting that KP-10 acting through GPR54 (KISS1R) inactivates NF-κB and MAPK signaling in macrophages, characterizing KISS1R-mediated intracellular signaling in a non-reproductive model.
Velora Research Insight
KP-10-specific KISS1R/GPR54 downstream-signaling mechanism (independent group). Demonstrates receptor-signaling breadth beyond the reproductive axis.
PubMed →DOI →
Clinical Trial•European Journal of Endocrinology• 2026

Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men

KP-10-specific human-physiology study reporting that chronic subcutaneous kisspeptin-10 administration stimulates gonadotropin secretion over 12 days in healthy men.
Velora Research Insight
KP-10-specific human neuroendocrine-physiology context (Imperial/Dhillo group). Cited as research context only, not a therapeutic representation.
PubMed →DOI →
Clinical Trial•Hormones (Athens)• 2026

Dynamic modulation of LH secretion by continuous kisspeptin infusion in healthy men

Independent human-physiology study reporting dynamic modulation of luteinizing-hormone secretion by continuous kisspeptin infusion in healthy men.
Velora Research Insight
Independent human neuroendocrine-physiology context (MGH / Seminara-Balasubramanian group). Research context only, not a therapeutic representation.
PubMed →DOI →