Ipamorelin | Peptide Reference Material
RESEARCH PEPTIDE

Ipamorelin | Peptide Reference Material

Selective Growth Hormone Secretagogue — Research Peptide
$29.00
Growth-hormone-secretagogue receptor agonist pentapeptide supplied as a lyophilized laboratory reference material. Research use only. Not for human or veterinary use.
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Primary Literature Peer-reviewed sources
Research Use Only Laboratory research materials

Scientific Specifications

Reference characteristics for laboratory research materials.

CAS Number
170851-70-4
Purity
≥98%
Molecular Formula
C38H49N9O5
Molecular Weight
711.85
Appearance
White lyophilized powder
Storage
-20°C
Research Classification
Research Use Only (RUO). Not for human or veterinary use.

SCIENTIFIC OVERVIEW

Scientific background and research classification for this laboratory reference material.

Ipamorelin (NNC 26-0161; CAS 170851-70-4) is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) developed as a growth hormone secretagogue. It was characterized as the first selective growth hormone secretagogue, stimulating growth hormone release through the ghrelin receptor / growth-hormone-secretagogue receptor (GHSR) without the concomitant release of other pituitary hormones seen with earlier secretagogues (Raun et al., 1998).

As a laboratory reference material, ipamorelin supports research into ghrelin-receptor pharmacology and growth-hormone-axis regulation in cellular and preclinical models. This material is supplied for laboratory research use only.

Primary Research Category
Growth Hormone Research
Material Type
Lyophilized Peptide
Intended Use
Laboratory Research
Research Categories
Growth Hormone Axis Endocrine Research Hormonal Regulation

Mechanism of Action

Molecular interaction profile describing how this research material engages receptor systems and influences downstream biological signaling pathways.

Ipamorelin acts as an agonist at the ghrelin receptor (GHSR), the growth-hormone-secretagogue receptor, stimulating growth hormone secretion from pituitary somatotrophs. Its defining pharmacological feature is selectivity: in the founding characterization it released growth hormone with potency comparable to earlier secretagogues but without stimulating ACTH, cortisol, or prolactin release (Raun et al., 1998). Somatotroph responsiveness to chronic ipamorelin has been examined independently in vitro (Jiménez-Reina et al., 2002).

Molecular Targets
  • Ghrelin Receptor (GHSR)
Primary Organ Systems
  • Endocrine System

Research Documentation

Laboratory documentation is presented when available for the selected product specification and current lot.

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Scientific References
Peer-Reviewed Literature

Explore published literature, clinical investigations, and foundational scientific research.

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Laboratory Resources
Technical Guidance

Storage guidance, handling recommendations, analytical methods, and laboratory best practices.

Related Research
Companion Materials

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Research Center

Scientific literature, laboratory resources, and related materials curated to support research involving this research material.

Scientific References
Peer-Reviewed Literature

Explore curated publications from peer-reviewed journals including clinical investigations, mechanistic studies, and foundational scientific literature.

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Scientific Dossier
Deeper Technical Treatment

Comprehensive scientific documentation including literature review, mechanism, pharmacology, and study data for this research material.

Laboratory Resources
Technical Guidance

Storage guidance, handling information, analytical standards, research policies, and laboratory support documentation.

Research Library

Curated peer-reviewed literature selected to provide scientific context for this research material.

Pharmacology Study•European Journal of Endocrinology• 1998

Ipamorelin, the first selective growth hormone secretagogue

Foundational pharmacological characterization of ipamorelin as the first selective growth hormone secretagogue, releasing growth hormone via the ghrelin/GHS receptor without stimulating ACTH, cortisol, or prolactin.
Velora Research Insight
Origin selectivity/receptor characterization. Novo Nordisk originating lineage — labeled as the founding, non-independent report.
PubMed →DOI →
Preclinical Study•Histology and Histopathology• 2002

Influence of chronic treatment with the growth hormone secretagogue Ipamorelin, in young female rats: somatotroph response in vitro

Independent preclinical study of chronic ipamorelin treatment in young female rats, characterizing the in-vitro somatotroph response.
Velora Research Insight
Independent (non-originator) preclinical characterization of pituitary somatotroph responsiveness to ipamorelin.
PubMed →DOI →
Preclinical Study•The Journal of Pharmacology and Experimental Therapeutics• 2009

Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus

Independent preclinical study characterizing ipamorelin as a ghrelin-receptor mimetic in a rodent model of postoperative ileus, extending its pharmacology to gastrointestinal-motility research.
Velora Research Insight
Independent replication of ghrelin-receptor agonism in a distinct model, reinforcing the GHSR target identity.
PubMed →DOI →
Preclinical Study•Growth Hormone & IGF Research• 2009

Growth hormone and growth hormone secretagogue effects on nitrogen balance and urea synthesis in steroid treated rats

Independent preclinical study examining growth hormone and growth-hormone-secretagogue effects on nitrogen balance and urea synthesis in steroid-treated rats.
Velora Research Insight
Independent preclinical context linking growth-hormone-secretagogue activity to metabolic (nitrogen/urea) endpoints.
PubMed →DOI →