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FOXO4-DRI | Reference Standard

$199.00
$199.00
Specification

    Product Details

    Peptide Inhibitor for Cellular Senescence & Aging Pathway Research

    Category:
    Longevity & Cellular Senescence • Apoptosis & DNA Damage Response • Aging Biology

     

    What Researchers Study

    FOXO4-DRI is a synthetic peptide designed to disrupt the interaction between FOXO4 (Forkhead box O4) and p53, a key protein involved in cell cycle regulation and apoptosis. Researchers study FOXO4-DRI as a mechanistic tool for investigating cellular senescence, a state in which damaged or aged cells cease dividing but resist programmed cell death.

    In laboratory and preclinical models, FOXO4-DRI is used to explore how selectively targeting senescent cells affects tissue function, aging pathways, and cellular homeostasis.

     

    Primary Signal Pathways Studied

    Research involving FOXO4-DRI focuses on its influence within:

    • FOXO transcription factor signaling, particularly FOXO4–p53 binding dynamics

    • p53-mediated apoptosis pathways, central to DNA damage response

    • Cellular senescence maintenance mechanisms, including survival signaling in aged cells

    • DNA damage and stress-response signaling, relevant to aging and degenerative models

    FOXO4-DRI is notable for its targeted mechanism, acting on protein–protein interactions rather than broadly altering transcription or metabolism.

     

    Why This Peptide Is Studied

    Senescent cells accumulate with age and contribute to tissue dysfunction through inflammatory signaling and impaired regeneration. Many senolytic strategies act broadly, increasing the risk of off-target effects.

    FOXO4-DRI is studied because it allows researchers to:

    • Examine selective vulnerability of senescent cells

    • Explore how disrupting survival signaling triggers apoptosis specifically in aged cells

    • Investigate links between senescence clearance and tissue resilience

    This makes FOXO4-DRI a critical research tool in aging biology, senescence modeling, and mechanistic longevity research.

     

    Research Areas of Interest

    Cellular Senescence & Aging Research

    FOXO4-DRI is widely studied in models evaluating senescent cell burden, lifespan markers, and age-associated tissue decline.

    DNA Damage & Stress-Response Biology

    Research examines how FOXO4-p53 interactions regulate cell survival following chronic DNA damage or oxidative stress.

    Regenerative & Tissue-Resilience Studies

    Exploratory work investigates how removal or modulation of senescent cells affects regenerative capacity and tissue function.

     

    Selected Scientific References

    • Baar et al., Cell — Targeted apoptosis of senescent cells via FOXO4-p53 disruption

    • Van Deursen et al., Nature Reviews Molecular Cell Biology — Cellular senescence in aging and disease

    • Campisi et al., Annual Review of Physiology — Senescence signaling and tissue dysfunction

    (References provided for educational context and literature navigation.)

     

    Product Specifications

    • Compound Name: FOXO4-DRI 

    • CAS Number: 2460055-10-9

    • Molecular Formula: C₂₂₈H₃₈₈N₈₆O₆₄

    • Amino Acid Sequence:                                                                                              

      Leu-Thr-Leu-Arg-Lys-Glu-Pro-Ala-Ser-Glu-Ile-Ala-Gln-Ser-Ile-Leu-Glu-Ala-Tyr-Ser-Gln-Asn-Gly-Trp-Ala-Asn-Arg-Arg-Ser-Gly-Gly-Lys-Arg-Pro-Pro-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly

    • Molecular Weight: 5358.15

    • Purity: ≥98% (HPLC verified)

    • Form: Lyophilized powder

    • Appearance: White to off-white solid

    • Storage: ≤ –20 °C, desiccated, protected from light

     

    Batch Documentation & Traceability

    Each vial is shipped with a lot-specific QR code that provides secure access to batch documentation, including:

    • Certificate of Analysis (COA)
    • Identity verification report (HPLC / MS)
    • Lot number, potency, and expiration

    Documentation is locked to the specific batch shipped to ensure traceability, version control, and research reproducibility.

    QR access is provided with the physical product and is not reused across lots.

     

    Research Use Disclaimer

    This product is supplied strictly for laboratory research and in-vitro or preclinical investigation.
    Not for human or veterinary use.
    Not for diagnostic, therapeutic, or consumptive applications.