DSIP | Peptide Reference Material
RESEARCH PEPTIDE

DSIP | Peptide Reference Material

Synthetic Nonapeptide — Research Peptide
$29.00
DSIP is a synthetic nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) studied in rabbit EEG experiments of delta and spindle activity. Research use only; not for human or veterinary use.
✓ Scientific Identity Established
⏳ Laboratory Testing In Progress
⏳ Batch Documentation Pending
✓ Research Use Only
✓ U.S. Fulfillment
In Laboratory Testing
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Primary Literature Peer-reviewed sources
Research Use Only Laboratory research materials

Scientific Specifications

Reference characteristics for laboratory research materials.

CAS Number
62568-57-4
Purity
≥98%
Molecular Formula
C35H48N10O15
Molecular Weight
848.81
Appearance
White lyophilized powder
Storage
-20°C
Research Classification
Research Use Only (RUO). Not for human or veterinary use.

SCIENTIFIC OVERVIEW

Scientific background and research classification for this laboratory reference material.

The supplier COA for DSIP lot P241013-A021 identifies a chemically synthesized peptide with sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, CAS 62568-57-4, formula C35H48N10O15, and reported molecular weight 848.9. Independent reference sources describe this sequence as the defined DSIP nonapeptide. Historical rabbit studies examined synthetic DSIP by intraventricular infusion and reported delta and spindle EEG enhancement; these observations are model-specific and do not establish a human physiological role or a defined receptor mechanism for the supplied material.

Material Type
Lyophilized Peptide
Intended Use
Laboratory Research
Research Categories
Neuroscience Sleep Biology

Mechanism of Action

Molecular interaction profile describing how this research material engages receptor systems and influences downstream biological signaling pathways.

No cloned or definitively characterized direct molecular receptor for DSIP has been established. Cultured rat brain-stem neurones showed saturable binding of radiolabeled DSIP, and transport studies described a saturable blood-brain-barrier process. These are binding and transport observations, not proof of a single receptor-mediated mechanism. The foundational rabbit EEG experiments observed delta and spindle changes after intraventricular exposure; they do not establish human activity, therapeutic benefit, or a causal molecular pathway.

Primary Organ Systems
  • Central Nervous System

Research Documentation

Laboratory documentation is presented when available for the selected product specification and current lot.

In Laboratory Testing
Laboratory Documentation In Progress

Laboratory documentation for the current lot is being completed.

Scientific References
Peer-Reviewed Literature

Explore published literature, clinical investigations, and foundational scientific research.

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Laboratory Resources
Technical Guidance

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Related Research
Companion Materials

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Research Center

Scientific literature, laboratory resources, and related materials curated to support research involving this research material.

Scientific References
Peer-Reviewed Literature

Explore curated publications from peer-reviewed journals including clinical investigations, mechanistic studies, and foundational scientific literature.

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Scientific Dossier
Deeper Technical Treatment

Comprehensive scientific documentation including literature review, mechanism, pharmacology, and study data for this research material.

Laboratory Resources
Technical Guidance

Storage guidance, handling information, analytical standards, research policies, and laboratory support documentation.

Research Library

Curated peer-reviewed literature selected to provide scientific context for this research material.

Preclinical Study•Proceedings of the National Academy of Sciences of the United States of America• 1977

Characterization of a delta-electroencephalogram (-sleep)-inducing peptide

Foundational report characterizing a delta-EEG (sleep)-inducing peptide isolated from cerebral venous blood of rabbits during electrically induced sleep — the discovery/origin of DSIP as a defined factor.
Velora Research Insight
Discovery/origin publication. Schoenenberger–Monnier Swiss originating group (Basel). Establishes the peptide's isolation and historical name; findings are animal-derived and foundational, not efficacy evidence in humans.
PubMed →DOI →
Structural Biology•Pflügers Archiv: European Journal of Physiology• 1978

The delta EEG (sleep)-inducing peptide (DSIP). XI. Amino-acid analysis, sequence, synthesis and activity of the nonapeptide

Determination of the DSIP nonapeptide amino-acid sequence, its chemical synthesis, and reported activity of the synthetic nonapeptide — the structural/identity basis for the governed molecular entity.
Velora Research Insight
Sequence-determination/synthesis publication establishing the WAGGDASGE nonapeptide identity. SAME Schoenenberger originating lineage as VSE-PUB-000092 (investigator concentration disclosed; not an independent lineage).
PubMed →DOI →
Mechanistic Study•European Neurology• 1984

Cellular localization of binding sites for 3H-DSIP on neurones of cultured rat brain stem

In-vitro autoradiographic study localizing specific binding sites for tritiated DSIP on cultured rat brain-stem neurones. Reports binding sites but does not identify or characterize a defined receptor.
Velora Research Insight
Binding-site localization (in vitro, rat brain stem). Basis for the molecular-target limitation: binding sites are reported, but no receptor is cloned/characterized. Co-authored by Schoenenberger — partial overlap with the originating lineage (disclosed).
PubMed →DOI →
Review Article•Journal of Neurochemistry• 2006

Delta sleep-inducing peptide (DSIP): a still unresolved riddle

Independent critical review concluding that, despite decades of study, DSIP's physiological role, mechanism, and reproducibility of reported sleep effects remain unresolved.
Velora Research Insight
Fully independent later critical synthesis (Kovalzon & Strekalova; no originating-group overlap). Explicitly preserves evidence-level uncertainty and cautions against treating the historical name as proof of sleep induction — the key claims-safety anchor for this graph.
PubMed →DOI →