5-AMINO-1-MQ | Reference Standard

NNMT Inhibitor for Metabolic & Longevity Signaling Studies

Category:
Metabolic Signaling • NAD⁺ Biology • Longevity Research • Small-Molecule Research Compounds

What Researchers Study

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small-molecule research compound studied for its ability to selectively inhibit nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular energy regulation and metabolic efficiency.

Researchers investigate 5-Amino-1MQ to better understand how NNMT activity influences NAD⁺ availability, mitochondrial function, and metabolic signaling in laboratory and preclinical models.

Primary Signal Pathways Studied

Research involving 5-Amino-1MQ focuses on its role in:

• NNMT inhibition, limiting conversion of nicotinamide (NAM) to 1-methylnicotinamide (1-MNA)

• NAD⁺ salvage and availability, a key factor in cellular energy and repair signaling

• Mitochondrial efficiency and oxidative metabolism

• Adipocyte and hepatic metabolic regulation

By modulating NNMT activity, 5-Amino-1MQ is studied as a tool to explore how metabolic enzymes influence systemic energy balance and cellular aging processes.

Why This Compound Is Studied

NNMT expression has been associated with metabolic dysfunction, obesity, and age-related declines in cellular efficiency. Traditional metabolic interventions often affect multiple pathways simultaneously, making mechanistic isolation difficult.

5-Amino-1MQ is studied as a targeted enzymatic inhibitor, allowing researchers to examine how suppressing NNMT alone impacts NAD⁺ metabolism, mitochondrial signaling, and downstream metabolic pathways without directly altering hormone signaling.

Research Areas of Interest

Metabolic & Energy Regulation

Preclinical studies explore how NNMT inhibition influences lipid metabolism, mitochondrial activity, and energy utilization in adipocyte and hepatic models.

Longevity & NAD⁺ Biology

Because NAD⁺ plays a central role in cellular repair, redox balance, and mitochondrial signaling, 5-Amino-1MQ is frequently studied in aging and longevity-focused research models.

Neuroenergetics & Cellular Resilience

Emerging research examines NNMT inhibition in neuronal and cognitive models, particularly related to cellular energy metabolism and resistance to metabolic stress.

Selected Scientific References

• Kraus et al., Nature Medicine (2018) — NNMT inhibition improves metabolic parameters and NAD⁺ availability in obesity models

• Neelakantan et al., Cell Metabolism (2019) — NNMT inhibition and adipose tissue metabolic remodeling

• Pissios et al., Aging Cell (2020) — NNMT activity and age-associated metabolic decline

• Jung et al., Hepatology Research (2021) — Effects of NNMT inhibition on lipid oxidation in hepatocyte models

(References provided for educational context and literature navigation.)

Product Specifications

• Compound Name: 5-Amino-1-MQ (5-Amino-1-methylquinolinium)

• CAS Number: 42464-96-0

• Molecular Formula: C₁₀H₁₁N₂⁺ (cation)

• Amino Acid Sequence: Not applicable (small-molecule compound)

• Molecular Weight: ~159.21 Da (free base)

• Purity: ≥98% (HPLC verified)

• Form: Solid powder

• Appearance: White to off-white crystalline material

• Storage: ≤ –20 °C, desiccated, protected from light

Batch Documentation & Traceability

Each vial is shipped with a lot-specific QR code that provides secure access to batch documentation, including:

• Certificate of Analysis (COA)
• Identity verification report (HPLC / MS)
• Lot number, potency, and expiration

Documentation is locked to the specific batch shipped to ensure traceability, version control, and research reproducibility.

QR access is provided with the physical product and is not reused across lots.

Research Use Disclaimer

This product is supplied strictly for laboratory research and in-vitro or preclinical investigation.
Not for human or veterinary use.
Not for diagnostic, therapeutic, or consumptive applications.