5-Amino-1-methylquinolinium chloride, laboratory presentation, laboratory reference material
RESEARCH MATERIAL

5-AMINO-1MQ | METABOLIC RESEARCH

5-Amino-1-methylquinolinium chloride — Small-Molecule NNMT Research Material
$49.00
5-Amino-1-methylquinolinium chloride supplied as a small-molecule laboratory research material for controlled NNMT and metabolic-regulation studies. Research use only. Not for human or veterinary use.
✓ Scientific Identity Established
⏳ Laboratory Testing In Progress
⏳ Batch Documentation Pending
✓ Research Use Only
✓ U.S. Fulfillment
In Laboratory Testing
Lot Verification Variant-specific documentation
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Primary Literature Peer-reviewed sources
Research Use Only Laboratory research materials

Scientific Specifications

Reference characteristics for laboratory research materials.

CAS Number
42464-96-0
Research Classification
Research Use Only (RUO). Not for human or veterinary use.

SCIENTIFIC OVERVIEW

Scientific background and research classification for this laboratory reference material.

5-Amino-1-methylquinolinium chloride is a quinolinium small-molecule research material used in preclinical studies of nicotinamide N-methyltransferase (NNMT) activity and cellular metabolic regulation. Published studies have characterized methylquinolinium inhibitors in biochemical, cell-based, animal, and pharmacokinetic research settings. This material is supplied for laboratory research use only.

Primary Research Category
Metabolic Research
Material Type
Lyophilized Small Molecule
Intended Use
Laboratory Research
Research Categories
Metabolic Signaling Energy Homeostasis

Mechanism of Action

Molecular interaction profile describing how this research material engages receptor systems and influences downstream biological signaling pathways.

Published biochemical and cell-based studies describe 5-Amino-1MQ as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that transfers a methyl group from S-adenosylmethionine to nicotinamide. Experimental NNMT inhibition has been used to study changes in 1-methylnicotinamide, NAD+, SAM, lipogenesis, and related metabolic pathways. These findings are preclinical and do not establish human safety or efficacy.

Primary Organ Systems
  • Metabolic System

Research Documentation

Laboratory documentation is presented when available for the selected product specification and current lot.

In Laboratory Testing
Laboratory Documentation In Progress

Laboratory documentation for the current lot is being completed.

Scientific References
Peer-Reviewed Literature

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Laboratory Resources
Technical Guidance

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Related Research
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Research Center

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Scientific References
Peer-Reviewed Literature

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Scientific Dossier
Deeper Technical Treatment

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Laboratory Resources
Technical Guidance

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Research Library

Curated peer-reviewed literature selected to provide scientific context for this research material.

Mechanistic Study•Journal of Medicinal Chemistry• 2017

Structure–Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase

Medicinal-chemistry study describing structure–activity relationships for methylquinolinium NNMT inhibitors, including the 5-amino substituted scaffold.
Velora Research Insight
Foundational compound-characterization evidence for the NNMT research context.
PubMed →DOI →Abstract →
Preclinical Study•Biochemical Pharmacology• 2018

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice

Preclinical biochemical, adipocyte, permeability, selectivity, and diet-induced-obesity mouse research on methylquinolinium NNMT inhibitors including 5-amino-1MQ.
Velora Research Insight
Direct preclinical evidence; it does not establish human use, safety, or efficacy.
PubMed →DOI →Abstract →
Preclinical Study•Scientific Reports• 2021

Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice

Mouse study of NNMT inhibitor treatment combined with dietary change, including body-composition, liver and adipose-tissue metabolomic endpoints.
Velora Research Insight
Supports preclinical metabolic research context only.
PubMed →DOI →Abstract →
Analytical Study•Journal of Pharmaceutical and Biomedical Analysis• 2021

Development & validation of LC–MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studies

Analytical-method validation for quantifying 5-amino-1-methyl quinolinium in rat plasma with application to preclinical pharmacokinetic and oral-bioavailability studies.
Velora Research Insight
Provides direct analytical and preclinical disposition context for the compound.
PubMed →DOI →Abstract →