VIP | Reference Standard

Advanced Research Compound for Immunomodulation, Neuroprotection & Gut–Brain Axis Studies

Category:
Neuropeptide Research • Immunology • Neuroinflammation • Gut–Brain Axis • Autoimmune Models

 

What Researchers Study

Vasoactive Intestinal Peptide (VIP) is a 28–amino acid endogenous neuropeptide belonging to the secretin/glucagon peptide family. It functions as a master regulatory signal across the nervous, immune, endocrine, and gastrointestinal systems.

VIP is extensively studied for its ability to:

• Suppress pathological inflammation

• Rebalance immune responses (Th1/Th2/Th17/Treg)

• Protect neurons and glial cells

• Stabilize epithelial barriers

• Coordinate gut–brain–immune signaling

Unlike single-pathway cytokine inhibitors, VIP acts as a systems-level immunoregulatory peptide, making it uniquely valuable in complex disease models.

 

Primary Signal Pathways Studied

• VPAC1 receptor signaling

• VPAC2 receptor signaling

• cAMP / PKA pathways

• NF-κB suppression

• MAPK modulation

• T-cell differentiation pathways

• Microglial activation control

• Intestinal epithelial barrier regulation

VIP signaling integrates neural input with immune output, a rare and powerful research axis.

 

Mechanism of Action (Research Context)

1. Immune System Modulation

VIP:

• Suppresses TNF-α, IL-1β, IL-6, IFN-γ

• Enhances IL-10 and TGF-β

• Shifts immune balance toward regulatory T-cell (Treg) dominance

• Inhibits antigen-presenting cell overactivation

This makes VIP a cornerstone peptide in autoimmune, inflammatory, and cytokine-storm research.

2. Neuroprotection & Neuroinflammation Control

In CNS models, VIP:

• Reduces microglial activation

• Protects neurons from excitotoxicity

• Preserves synaptic signaling

• Modulates astrocyte inflammatory output

It is heavily studied in:

• Neurodegeneration

• Traumatic brain injury

• Stroke and ischemia models

• Neuroimmune crosstalk

3. Gut–Brain Axis & Barrier Integrity

VIP regulates:

• Intestinal smooth muscle tone

• Epithelial tight junctions

• Mucosal immune tolerance

• Enteric nervous system signaling

This positions VIP as a central peptide in IBD, leaky gut, and microbiome-immune research.

 

Key Research Domains

1. Autoimmune & Inflammatory Disease Models

VIP has demonstrated efficacy in:

• Rheumatoid arthritis models

• Multiple sclerosis (EAE) models

• Lupus-like immune dysregulation

• Inflammatory bowel disease (IBD)

Its value lies in immune rebalancing, not blanket suppression.

2. Neurodegenerative & Neuroinflammatory Research

VIP is used to study:

• Microglial-mediated neurotoxicity

• Astrocyte cytokine signaling

• Neuronal survival under oxidative stress

• CNS immune privilege maintenance

3. Pulmonary & Vascular Research

VIP is a potent:

• Vasodilator

• Bronchodilator

• Pulmonary endothelial stabilizer

Research areas include:

• Pulmonary hypertension

• Acute lung injury

• Endothelial dysfunction

4. Gastrointestinal & Mucosal Immunology

VIP supports:

• Gut immune tolerance

• Epithelial repair

• Reduction of intestinal inflammation

• Neural control of peristalsis

 

Why VIP Is a Cornerstone Research Peptide

• Systems-level immune control

• CNS + immune + gut integration

• Non-cytotoxic immune modulation

• High relevance to autoimmune and neuroinflammatory disease

• Difficult to replace with small molecules

 

Product Specifications

• Compound Name: Vasoactive Intestinal Peptide (VIP)

• CAS Number: 40077-57-4

• Molecular Formula: C₁₄₇H₂₃₈N₄₄O₄₂S

• Molecular Weight: 3,325 Da

• Amino Acid Length: 28

• Purity: ≥98% (HPLC verified)

• Form: Lyophilized powder

• Appearance: White to off-white solid

 

Batch Documentation & Traceability

Each vial is shipped with a lot-specific QR code that provides secure access to batch documentation, including:

• Certificate of Analysis (COA)
• Identity verification report (HPLC / MS)
• Lot number, potency, and expiration

Documentation is locked to the specific batch shipped to ensure traceability, version control, and research reproducibility.

QR access is provided with the physical product and is not reused across lots.

 

Research Use Disclaimer

This compound is supplied strictly for laboratory research purposes.
Not for human or veterinary consumption, diagnosis, or treatment.