SELANK

Anxiolytic, Cognitive & Neuroimmune Signaling Research

Category:
Neuropeptide Signaling • Cognitive Function • Stress & Anxiety Pathways • Neuroimmune Modulation

 

What Researchers Study

Selank is a synthetic heptapeptide analog of tuftsin, an endogenous immunomodulatory peptide derived from IgG. It was developed to investigate anxiety regulation, cognitive enhancement, and neuroimmune balance without the sedative or dependency-forming effects associated with traditional anxiolytics.

Researchers study Selank because it:

• Modulates GABAergic signaling without direct receptor agonism

• Influences serotonergic and dopaminergic tone

• Exhibits immunomodulatory activity

• Demonstrates cognitive and anxiolytic effects without sedation

Selank occupies a unique position as a functional neuromodulator, rather than a classical neurotransmitter mimic.

 

Primary Signal Pathways Studied

• GABAergic tone modulation (indirect)

• Serotonin (5-HT) signaling balance

• Dopamine pathway regulation

• BDNF and neuroplasticity markers

• Cytokine signaling and immune–brain interaction

• Stress-response axis (HPA modulation)

 

Why This Molecule Is Studied

Selank allows researchers to study anxiety and cognition as network phenomena, rather than single-receptor events.

Unlike benzodiazepines or SSRIs, Selank:

• Does not directly bind GABA-A or serotonin receptors

• Does not produce sedation or motor impairment

• Does not induce tolerance or withdrawal in research models

This makes it especially valuable for longitudinal cognitive and behavioral studies.

 

Mechanistic Overview

Selank exerts its effects through gene expression modulation and synaptic signaling balance, rather than acute receptor stimulation.

Key observed mechanisms include:

• Normalization of GABA/Glutamate balance

• Modulation of monoamine turnover

• Upregulation of BDNF and synaptic plasticity genes

• Regulation of pro- and anti-inflammatory cytokines

These effects collectively support emotional stability, learning, and stress resilience.

 

Key Research Domains

1. Anxiety & Stress Regulation

Selank is widely studied in:

• Anxiety models

• Stress-induced behavioral dysregulation

• Fear-conditioning paradigms

Notably, anxiolytic effects occur without sedation, making it ideal for behavioral testing.

2. Cognitive Function & Memory

Research explores Selank’s role in:

• Learning acquisition

• Memory consolidation

• Attention and executive function

Often studied alongside Semax to compare complementary cognitive signaling pathways.

3. Neuroimmune Interaction

As a tuftsin analog, Selank demonstrates:

• Modulation of cytokine expression

• Regulation of immune cell signaling

• Reduction of neuroinflammation markers

This positions Selank within psychoneuroimmunology research.

4. Emotional Regulation Without Dependency

Selank enables investigation of:

• Non-sedative anxiolysis

• Long-term emotional regulation

• Absence of tolerance or withdrawal phenomena

This makes it especially useful for chronic model designs.

 

Research Context Considerations

• Effects are state-dependent

• Cognitive outcomes vary with baseline stress levels

• Often shows synergy with other nootropic peptides

• Species differences in behavioral response should be considered

 

Product Specifications

• Compound Name: Selank

• CAS Number: 129954-34-3

• Molecular Formula: C₃₃H₅₇N₁₁O₉

• Molecular Weight: 751.87 Da

• Amino Acid Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro

• Peptide Class: Synthetic tuftsin analog (heptapeptide)

• Purity: ≥98% (HPLC verified)

• Form: Lyophilized powder

• Appearance: White to off-white solid

• Storage: ≤ –20 °C, desiccated, protected from light

 

Batch Documentation & Traceability

Each vial is shipped with a lot-specific QR code that provides secure access to batch documentation, including:

• Certificate of Analysis (COA)
• Identity verification report (HPLC / MS)
• Lot number, potency, and expiration

Documentation is locked to the specific batch shipped to ensure traceability, version control, and research reproducibility.

QR access is provided with the physical product and is not reused across lots.

 

Research Use Disclaimer

This compound is supplied exclusively for laboratory research use.
Not for human or veterinary use.
Not for diagnostic, therapeutic, or consumptive applications.