IPAMORELIN | Reference Standard

Selective Ghrelin Receptor Agonist for Growth Hormone Signaling Research

Category:
Endocrine & Hormonal Signaling • Growth Hormone Axis Research • Metabolic Signaling

What Researchers Study

Ipamorelin is a synthetic pentapeptide growth hormone secretagogue studied for its ability to stimulate endogenous growth hormone (GH) release through activation of the ghrelin receptor (GHS-R1a). Unlike some earlier GHRPs, ipamorelin is investigated for its selectivity, with comparatively limited interaction with other pituitary hormone pathways in experimental models.

In laboratory and preclinical settings, ipamorelin is used to examine ghrelin-mediated GH signaling while minimizing confounding endocrine activation.

Primary Signal Pathways Studied

Research involving ipamorelin focuses on:

• Ghrelin receptor (GHS-R1a) activation, independent of GHRH receptor signaling

• Endogenous GH secretion dynamics, via pituitary somatotroph stimulation

• Neuroendocrine feedback regulation, linking hypothalamic and pituitary signaling

• Metabolic and nutrient-response pathways, associated with ghrelin signaling

Because of its receptor selectivity, ipamorelin is frequently used in comparative secretagogue studies alongside GHRP-6, GHRP-2, and GHRH analogs.

Why This Peptide Is Studied

Growth hormone secretion can be stimulated through multiple overlapping mechanisms, including GHRH-dependent and ghrelin-mediated pathways. Many compounds activate several endocrine axes simultaneously, complicating interpretation.

Ipamorelin is studied because it allows researchers to:

• Isolate ghrelin-specific GH signaling

• Compare selective vs broad GHRP activity

• Examine GH release without pronounced activation of other pituitary hormones

• Model endocrine signaling with reduced systemic interference

This makes ipamorelin a useful tool in endocrine physiology, metabolic signaling, and GH axis research.

Research Areas of Interest

Growth Hormone Axis Research

Ipamorelin is studied in pituitary and hypothalamic models to assess GH release kinetics and receptor-specific signaling behavior.

Metabolic & Nutrient Signaling

Because ghrelin receptors are involved in metabolic sensing, ipamorelin is explored in studies examining GH-linked metabolic coordination.

Comparative GHRP Research

Ipamorelin is commonly evaluated alongside other GHRPs to understand differences in receptor engagement, signaling selectivity, and endocrine response profiles.

Selected Scientific References

• Raun et al., Endocrinology — Characterization of ipamorelin as a selective GH secretagogue

• Bowers et al., Journal of Endocrinology — Ghrelin receptor–mediated GH release

• Kojima et al., Nature — Ghrelin signaling and endocrine regulation

(References provided for educational context and literature navigation.)

Product Specifications

• Compound Name: Ipamorelin

• CAS Number: 170851-70-4

• Molecular Formula: C₃₈H₄₉N₉O₅

• Amino Acid Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2

• Molecular Weight: 712.03 Da

• Purity: ≥99% (HPLC verified)

• Form: Lyophilized powder

• Appearance: White to off-white solid

• Storage: ≤ –20 °C, desiccated, protected from light

Batch Documentation & Traceability

Each vial is shipped with a lot-specific QR code that provides secure access to batch documentation, including:

• Certificate of Analysis (COA)
• Identity verification report (HPLC / MS)
• Lot number, potency, and expiration

Documentation is locked to the specific batch shipped to ensure traceability, version control, and research reproducibility.

QR access is provided with the physical product and is not reused across lots.

Research Use Disclaimer

This product is supplied strictly for laboratory research and in-vitro or preclinical investigation.
Not for human or veterinary use.
Not for diagnostic, therapeutic, cosmetic, or consumptive applications.