CARGRILINTIDE | Reference Standard

Long-Acting Amylin Analog for Metabolic & Appetite Signaling Research

Category:
Metabolic Signaling • Appetite & Energy Regulation • Endocrine Research

What Researchers Study

Cagrilintide is a long-acting synthetic peptide analog of amylin, a hormone co-secreted with insulin that plays a role in appetite regulation, gastric emptying, and energy balance. Researchers study cagrilintide to better understand central and peripheral satiety signaling and how amylin receptor modulation influences metabolic behavior in preclinical models.

The peptide is structurally modified to enhance stability and extend biological activity compared to native amylin, making it suitable for sustained signaling studies.

Primary Signal Pathways Studied

Research involving cagrilintide focuses on:

• Amylin receptor activation (AMY receptors, composed of calcitonin receptor complexes)

• Central appetite and satiety signaling, particularly within hypothalamic pathways

• Gastric emptying and nutrient flow regulation

• Energy balance and metabolic coordination, especially in obesity and metabolic-dysregulation models

Cagrilintide is frequently studied alongside other metabolic peptides to examine complementary or overlapping signaling mechanisms.

Why This Peptide Is Studied

Native amylin has a short half-life and limited stability, restricting its usefulness in extended research models. Cagrilintide was developed to allow researchers to:

• Examine sustained amylin receptor signaling

• Study appetite regulation independently of insulin or incretin pathways

• Explore combinatorial metabolic signaling strategies in preclinical systems

Its long-acting design makes it valuable for comparative metabolic research and energy-regulation modeling.

Research Areas of Interest

Appetite & Satiety Signaling

Cagrilintide is widely studied in models investigating central appetite control, food-intake behavior, and satiety-related neural circuits.

Metabolic & Energy Balance Research

Research explores how amylin analogs influence body-weight regulation, nutrient handling, and systemic metabolic coordination.

Combination Peptide Research

Cagrilintide is often examined in combination frameworks to understand how amylin signaling interacts with other endocrine or metabolic pathways.

Selected Scientific References

• Larsen et al., Diabetes, Obesity and Metabolism — Amylin analogs and appetite regulation

• Holst et al., Nature Reviews Endocrinology — Central mechanisms of metabolic peptide signaling

• Amylin receptor signaling literature — Calcitonin receptor complex biology

(References provided for educational context and literature navigation.)

Product Specifications

• Compound Name: Cagrilintide 

• CAS Number: 1415456-99-3

• Molecular Formula: C₁₉₄H₃₁₂N₅₄O₅₉S₂

• Amino Acid Sequence: 

  {Eicosanedioic acid-γ-Glu}-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Pro-NH₂

• Molecular Weight: ~4,409 Da

• Purity: ≥98% (HPLC verified)

• Form: Lyophilized powder

• Appearance: White to off-white solid

• Storage: ≤ –20 °C, desiccated, protected from light

Batch Documentation & Traceability

Each vial is shipped with a lot-specific QR code that provides secure access to batch documentation, including:

• Certificate of Analysis (COA)
• Identity verification report (HPLC / MS)
• Lot number, potency, and expiration

Documentation is locked to the specific batch shipped to ensure traceability, version control, and research reproducibility.

QR access is provided with the physical product and is not reused across lots.

Research Use Disclaimer

This product is supplied strictly for laboratory research and in-vitro or preclinical investigation.
Not for human or veterinary use.
Not for diagnostic, therapeutic, or consumptive applications.