AOD-9604 | Reference Standard

Synthetic hGH Fragment for Metabolic & Cartilage Research

Category:
Metabolic Signaling • Cartilage & Bone Biology • Peptide Research Compounds

What Researchers Study

AOD-9604 is a synthetic peptide fragment derived from the C-terminal region of human growth hormone (hGH). Researchers study this compound for its ability to influence fat metabolism and cartilage biology without activating the full growth-promoting pathways associated with intact growth hormone.

In laboratory models, AOD-9604 is explored as a targeted signaling fragment, designed to isolate specific metabolic and structural effects while minimizing broader endocrine activation.

Primary Signal Pathways Studied

From a mechanistic standpoint, AOD-9604 is investigated for its interaction with:

• Adipocyte lipid metabolism signaling, including pathways involved in lipolysis and fat oxidation

• Chondrocyte activity and extracellular matrix synthesis, particularly collagen and proteoglycan production

• Non-somatogenic GH-related signaling, distinct from classical GH receptor–IGF-1 activation

Importantly, published preclinical research suggests that AOD-9604 does not significantly stimulate IGF-1 production, making it a useful tool for studying dissociated growth hormone fragment activity.

Why This Peptide Is Studied

Full-length growth hormone influences many biological systems simultaneously, making it difficult to isolate specific effects in experimental models. AOD-9604 was developed as a precision fragment to help researchers examine:

• Whether metabolic effects of hGH can occur independently of growth signaling

• How targeted peptide fragments influence adipose tissue behavior

• Potential cartilage-specific signaling mechanisms separate from systemic growth effects

This makes AOD-9604 particularly useful in metabolic research, orthopedic biology, and comparative hormone signaling studies.

Research Areas of Interest

Metabolic & Adipocyte Research

In vitro and animal studies have explored AOD-9604’s role in lipid mobilization and fat metabolism. Published research in obesity models has reported reductions in fat mass without corresponding increases in circulating IGF-1, supporting the concept of pathway dissociation.

Cartilage & Connective Tissue Research

Separate lines of investigation examine AOD-9604’s effects on chondrocyte proliferation and cartilage matrix production. Experimental models have reported increased synthesis of collagen and glycosaminoglycans, which are foundational components of healthy cartilage tissue.

Selected Scientific References

• Heffernan et al., International Journal of Obesity (2001) — Investigation of metabolic effects of AOD-9604 compared to full-length hGH in obese animal models

• Wang et al., Osteoarthritis and Cartilage (2013, abstract) — In-vitro analysis of AOD-9604–mediated chondrogenesis

(References provided for educational context and literature navigation.)

Product Specifications

• Compound Name: AOD-9604

• CAS Number: 221231-10-3

• Molecular Formula: C₇₈H₁₂₃N₂₃O₂₃S₂

• Amino Acid Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe

• Molecular Weight: ~1,815.1 Da

• Purity: ≥98% (HPLC verified)

• Form: Lyophilized powder

• Appearance: White to off-white solid

• Storage: ≤ –20 °C, desiccated, protected from light

Batch Documentation & Traceability

Each vial is shipped with a lot-specific QR code that provides secure access to batch documentation, including:

• Certificate of Analysis (COA)
• Identity verification report (HPLC / MS)
• Lot number, potency, and expiration

Documentation is locked to the specific batch shipped to ensure traceability, version control, and research reproducibility.

QR access is provided with the physical product and is not reused across lots.

Research Use Disclaimer

This product is supplied strictly for laboratory research and in-vitro investigation.
Not for human or veterinary use.
Not for diagnostic, therapeutic, or consumptive applications.