IGF-1 LR3 | Reference Standard

Long-Acting IGF-1 Analog for Growth Factor & Cellular Signaling Research

Category:
Growth Factor Signaling • Cellular Proliferation & Repair • Metabolic & Endocrine Research

What Researchers Study

IGF-1 LR3 (Insulin-Like Growth Factor-1 Long Arg3) is a modified analog of native IGF-1 engineered to exhibit reduced binding to IGF-binding proteins (IGFBPs) and prolonged biological persistence in experimental systems.

Researchers study IGF-1 LR3 to examine direct IGF-1 receptor (IGF-1R) signaling with fewer regulatory constraints than endogenous IGF-1, allowing clearer investigation of growth-factor–mediated cellular processes in laboratory and preclinical models.

Primary Signal Pathways Studied

Research involving IGF-1 LR3 focuses on:

• IGF-1 receptor (IGF-1R) activation, triggering intracellular growth-factor signaling

• PI3K–AKT–mTOR pathways, associated with cell survival and metabolism

• MAPK/ERK signaling, involved in proliferation and differentiation

• Cellular glucose uptake and metabolic signaling, overlapping with insulin pathways

• Reduced IGF-binding protein interaction, enabling sustained receptor engagement

IGF-1 LR3 is used to study direct growth-factor signaling, rather than upstream hormonal regulation.

Why This Compound Is Studied

Native IGF-1 is tightly regulated by binding proteins that limit receptor availability and signaling duration. While biologically necessary, this regulation complicates mechanistic research.

IGF-1 LR3 is studied because it allows researchers to:

• Examine unrestricted IGF-1R signaling dynamics

• Investigate downstream anabolic and survival pathways more directly

• Compare regulated vs extended growth-factor signaling

• Model cellular responses to sustained IGF-1 receptor activation

This makes IGF-1 LR3 a key tool in cell biology, growth-factor research, and metabolic signaling studies.

Research Areas of Interest

Cellular Proliferation & Survival

IGF-1 LR3 is widely studied in models examining cell growth, apoptosis resistance, and tissue-repair signaling.

Metabolic & Insulin-Related Signaling

Because IGF-1 signaling overlaps with insulin pathways, the compound is explored in metabolic and glucose-handling research.

Tissue Repair & Regenerative Biology

Research investigates how sustained IGF-1 receptor activation influences muscle, connective tissue, and organ-level repair processes in preclinical models.

Selected Scientific References

• LeRoith et al., Endocrine Reviews — Biology of IGF-1 and IGF-1 receptor signaling

• Jones & Clemmons, Endocrine Reviews — IGF-binding proteins and growth-factor regulation

• Saltiel & Kahn, Nature — Growth-factor and insulin signaling convergence

(References provided for educational context and literature navigation.)

Product Specifications

• Compound Name: IGF-1 LR3

• CAS Number: 946870-92-4

• Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉

• Amino Acid Sequence:
  

  Gly-Pro-Glu-Thr-Leu-Cys-Gly-Ala-Glu-Leu-Val-Asp-Ala-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-Gly-Ile-Val-Asp-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Glu-Met-Tyr-Cys-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Ala

• Molecular Weight: 9,117.5 Da

• Purity: ≥98% (HPLC verified)
• Form: Lyophilized powder
• Appearance: White to off-white solid

• Storage: ≤ –20 °C, desiccated, protected from light

Batch Documentation & Traceability

Each vial is shipped with a lot-specific QR code that provides secure access to batch documentation, including:

• Certificate of Analysis (COA)
• Identity verification report (HPLC / MS)
• Lot number, potency, and expiration

Documentation is locked to the specific batch shipped to ensure traceability, version control, and research reproducibility.

QR access is provided with the physical product and is not reused across lots.

Research Use Disclaimer

This product is supplied strictly for laboratory research and in-vitro or preclinical investigation.
Not for human or veterinary use.
Not for diagnostic, therapeutic, or consumptive applications.