{"product_id":"pt-141-peptide","title":"PT-141 Peptide | Melanocortin Research","description":"\u003ch3 data-end=\"617\" data-start=\"519\"\u003eCentral Nervous System Melanocortin Signaling, Neuroendocrine \u0026amp; Behavioral Modulation Research\u003c\/h3\u003e\n\u003cp data-end=\"749\" data-start=\"619\"\u003e\u003cstrong data-end=\"632\" data-start=\"619\"\u003eCategory:\u003c\/strong\u003e\u003cbr data-end=\"635\" data-start=\"632\"\u003eNeuroendocrine Signaling • Melanocortin Receptor Biology • Behavioral Neuroscience • Autonomic Regulation Research\u003c\/p\u003e\n\u003cp data-end=\"749\" data-start=\"619\"\u003e \u003c\/p\u003e\n\u003ch2 data-end=\"785\" data-start=\"756\"\u003e\u003cstrong data-end=\"785\" data-start=\"759\"\u003eWhat Researchers Study\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-end=\"1034\" data-start=\"786\"\u003ePT-141 (Bremelanotide) is a \u003cstrong data-end=\"870\" data-start=\"814\"\u003esynthetic heptapeptide melanocortin receptor agonist\u003c\/strong\u003e and an active metabolite of \u003cstrong data-end=\"915\" data-start=\"899\"\u003eMelanotan II\u003c\/strong\u003e, engineered to preferentially target \u003cstrong data-end=\"986\" data-start=\"953\"\u003ecentral melanocortin pathways\u003c\/strong\u003e rather than peripheral pigmentation mechanisms.\u003c\/p\u003e\n\u003cp data-end=\"1072\" data-start=\"1036\"\u003eResearchers study PT-141 because it:\u003c\/p\u003e\n\u003cul data-end=\"1321\" data-start=\"1073\"\u003e\n\u003cli data-end=\"1110\" data-start=\"1073\"\u003e\n\u003cp data-end=\"1110\" data-start=\"1075\"\u003e\u003cstrong data-end=\"1110\" data-start=\"1075\"\u003eCrosses the blood–brain barrier\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"1155\" data-start=\"1111\"\u003e\n\u003cp data-end=\"1155\" data-start=\"1113\"\u003ePreferentially activates \u003cstrong data-end=\"1155\" data-start=\"1138\"\u003eMC4R and MC3R\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"1240\" data-start=\"1156\"\u003e\n\u003cp data-end=\"1240\" data-start=\"1158\"\u003eProduces \u003cstrong data-end=\"1240\" data-start=\"1167\"\u003ecentral nervous system effects independent of peripheral vasodilation\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"1321\" data-start=\"1241\"\u003e\n\u003cp data-end=\"1321\" data-start=\"1243\"\u003eAllows isolation of \u003cstrong data-end=\"1321\" data-start=\"1263\"\u003emelanocortin-driven behavioral and autonomic signaling\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-end=\"1443\" data-start=\"1323\"\u003eThis makes PT-141 uniquely valuable for studying \u003cstrong data-end=\"1442\" data-start=\"1372\"\u003emotivation, reward, autonomic tone, and neuroendocrine integration\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp data-end=\"1443\" data-start=\"1323\"\u003e \u003c\/p\u003e\n\u003ch2 data-end=\"1488\" data-start=\"1450\"\u003e\u003cstrong data-end=\"1488\" data-start=\"1453\"\u003ePrimary Signal Pathways Studied\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-end=\"1516\" data-start=\"1489\"\u003ePT-141 research focuses on:\u003c\/p\u003e\n\u003cul data-end=\"1792\" data-start=\"1518\"\u003e\n\u003cli data-end=\"1564\" data-start=\"1518\"\u003e\n\u003cp data-end=\"1564\" data-start=\"1520\"\u003e\u003cstrong data-end=\"1564\" data-start=\"1520\"\u003eMelanocortin-4 receptor (MC4R) signaling\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"1612\" data-start=\"1565\"\u003e\n\u003cp data-end=\"1612\" data-start=\"1567\"\u003e\u003cstrong data-end=\"1612\" data-start=\"1567\"\u003eMelanocortin-3 receptor (MC3R) modulation\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"1657\" data-start=\"1613\"\u003e\n\u003cp data-end=\"1657\" data-start=\"1615\"\u003e\u003cstrong data-end=\"1657\" data-start=\"1615\"\u003eHypothalamic neural circuit activation\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"1703\" data-start=\"1658\"\u003e\n\u003cp data-end=\"1703\" data-start=\"1660\"\u003e\u003cstrong data-end=\"1703\" data-start=\"1660\"\u003eDopaminergic reward pathway interaction\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"1750\" data-start=\"1704\"\u003e\n\u003cp data-end=\"1750\" data-start=\"1706\"\u003e\u003cstrong data-end=\"1750\" data-start=\"1706\"\u003eNitric oxide signaling within CNS nuclei\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"1792\" data-start=\"1751\"\u003e\n\u003cp data-end=\"1792\" data-start=\"1753\"\u003e\u003cstrong data-end=\"1792\" data-start=\"1753\"\u003eSympathetic–parasympathetic balance\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2 data-end=\"1834\" data-start=\"1799\"\u003e\u003cstrong data-end=\"1834\" data-start=\"1802\"\u003eWhy This Molecule Is Studied\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-end=\"1921\" data-start=\"1835\"\u003eUnlike many peptides that act peripherally, PT-141 is studied specifically because it:\u003c\/p\u003e\n\u003cul data-end=\"2166\" data-start=\"1923\"\u003e\n\u003cli data-end=\"1960\" data-start=\"1923\"\u003e\n\u003cp data-end=\"1960\" data-start=\"1925\"\u003eProduces \u003cstrong data-end=\"1960\" data-start=\"1934\"\u003edirect central effects\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"2040\" data-start=\"1961\"\u003e\n\u003cp data-end=\"2040\" data-start=\"1963\"\u003eSeparates \u003cstrong data-end=\"2010\" data-start=\"1973\"\u003emelanocortin behavioral signaling\u003c\/strong\u003e from MC1R-driven pigmentation\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"2104\" data-start=\"2041\"\u003e\n\u003cp data-end=\"2104\" data-start=\"2043\"\u003eAllows examination of \u003cstrong data-end=\"2104\" data-start=\"2065\"\u003ebrain-initiated autonomic responses\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"2166\" data-start=\"2105\"\u003e\n\u003cp data-end=\"2166\" data-start=\"2107\"\u003eExhibits predictable, receptor-specific activation profiles\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-end=\"2298\" data-start=\"2168\"\u003eIts CNS penetrance enables \u003cstrong data-end=\"2257\" data-start=\"2195\"\u003eprecise mechanistic study of melanocortin-driven behaviors\u003c\/strong\u003e without confounding peripheral pathways.\u003c\/p\u003e\n\u003cp data-end=\"2298\" data-start=\"2168\"\u003e \u003c\/p\u003e\n\u003ch2 data-end=\"2332\" data-start=\"2305\"\u003e\u003cstrong data-end=\"2332\" data-start=\"2308\"\u003eMechanistic Overview\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-end=\"2419\" data-start=\"2333\"\u003ePT-141 binds primarily to \u003cstrong data-end=\"2367\" data-start=\"2359\"\u003eMC4R\u003c\/strong\u003e, a G-protein–coupled receptor densely expressed in:\u003c\/p\u003e\n\u003cul data-end=\"2486\" data-start=\"2421\"\u003e\n\u003cli data-end=\"2437\" data-start=\"2421\"\u003e\n\u003cp data-end=\"2437\" data-start=\"2423\"\u003eHypothalamus\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"2455\" data-start=\"2438\"\u003e\n\u003cp data-end=\"2455\" data-start=\"2440\"\u003eLimbic system\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"2486\" data-start=\"2456\"\u003e\n\u003cp data-end=\"2486\" data-start=\"2458\"\u003eBrainstem autonomic nuclei\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-end=\"2508\" data-start=\"2488\"\u003eActivation leads to:\u003c\/p\u003e\n\u003cul data-end=\"2655\" data-start=\"2509\"\u003e\n\u003cli data-end=\"2555\" data-start=\"2509\"\u003e\n\u003cp data-end=\"2555\" data-start=\"2511\"\u003eIncreased neuronal firing (c-Fos expression)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"2589\" data-start=\"2556\"\u003e\n\u003cp data-end=\"2589\" data-start=\"2558\"\u003eModulation of dopaminergic tone\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"2616\" data-start=\"2590\"\u003e\n\u003cp data-end=\"2616\" data-start=\"2592\"\u003eAltered autonomic output\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"2655\" data-start=\"2617\"\u003e\n\u003cp data-end=\"2655\" data-start=\"2619\"\u003eContext-dependent behavioral changes\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-end=\"2846\" data-start=\"2657\"\u003eNotably, \u003cstrong data-end=\"2739\" data-start=\"2666\"\u003ePT-141 does not rely on nitric-oxide–mediated peripheral vasodilation\u003c\/strong\u003e, distinguishing it from erectile-focused compounds and making it ideal for \u003cstrong data-end=\"2845\" data-start=\"2815\"\u003ecentral signaling research\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp data-end=\"2846\" data-start=\"2657\"\u003e \u003c\/p\u003e\n\u003ch2 data-end=\"2880\" data-start=\"2853\"\u003e\u003cstrong data-end=\"2880\" data-start=\"2856\"\u003eKey Research Domains\u003c\/strong\u003e\u003c\/h2\u003e\n\u003ch3 data-end=\"2926\" data-start=\"2882\"\u003e\u003cstrong data-end=\"2926\" data-start=\"2886\"\u003e1. Central Nervous System Activation\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-end=\"2947\" data-start=\"2927\"\u003eStudies demonstrate:\u003c\/p\u003e\n\u003cul data-end=\"3047\" data-start=\"2948\"\u003e\n\u003cli data-end=\"2971\" data-start=\"2948\"\u003e\n\u003cp data-end=\"2971\" data-start=\"2950\"\u003eRapid BBB penetration\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3004\" data-start=\"2972\"\u003e\n\u003cp data-end=\"3004\" data-start=\"2974\"\u003eHypothalamic neuron activation\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3047\" data-start=\"3005\"\u003e\n\u003cp data-end=\"3047\" data-start=\"3007\"\u003eSustained receptor engagement over hours\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-end=\"3130\" data-start=\"3049\"\u003ePT-141 is frequently used in \u003cstrong data-end=\"3095\" data-start=\"3078\"\u003ec-Fos mapping\u003c\/strong\u003e and receptor localization studies.\u003c\/p\u003e\n\u003ch3 data-end=\"3186\" data-start=\"3137\"\u003e\u003cstrong data-end=\"3186\" data-start=\"3141\"\u003e2. Behavioral \u0026amp; Motivational Neuroscience\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-end=\"3211\" data-start=\"3187\"\u003ePT-141 is used to study:\u003c\/p\u003e\n\u003cul data-end=\"3313\" data-start=\"3212\"\u003e\n\u003cli data-end=\"3232\" data-start=\"3212\"\u003e\n\u003cp data-end=\"3232\" data-start=\"3214\"\u003eMotivated behavior\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3251\" data-start=\"3233\"\u003e\n\u003cp data-end=\"3251\" data-start=\"3235\"\u003eReward valuation\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3283\" data-start=\"3252\"\u003e\n\u003cp data-end=\"3283\" data-start=\"3254\"\u003eEffort-based task performance\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3313\" data-start=\"3284\"\u003e\n\u003cp data-end=\"3313\" data-start=\"3286\"\u003eBehavioral state modulation\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-end=\"3412\" data-start=\"3315\"\u003eIts effects are \u003cstrong data-end=\"3350\" data-start=\"3331\"\u003estate-dependent\u003c\/strong\u003e, making it useful for dissecting contextual neural responses.\u003c\/p\u003e\n\u003ch3 data-end=\"3467\" data-start=\"3419\"\u003e\u003cstrong data-end=\"3467\" data-start=\"3423\"\u003e3. Autonomic \u0026amp; Neuroendocrine Regulation\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-end=\"3483\" data-start=\"3468\"\u003eResearch shows:\u003c\/p\u003e\n\u003cul data-end=\"3617\" data-start=\"3484\"\u003e\n\u003cli data-end=\"3516\" data-start=\"3484\"\u003e\n\u003cp data-end=\"3516\" data-start=\"3486\"\u003eCentral sympathetic activation\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3558\" data-start=\"3517\"\u003e\n\u003cp data-end=\"3558\" data-start=\"3519\"\u003eModulation of cardiovascular parameters\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3617\" data-start=\"3559\"\u003e\n\u003cp data-end=\"3617\" data-start=\"3561\"\u003eThermoregulatory effects via hypothalamic MC4R signaling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-end=\"3702\" data-start=\"3619\"\u003eThis positions PT-141 as a tool for \u003cstrong data-end=\"3701\" data-start=\"3655\"\u003ebrain-initiated autonomic control research\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp data-end=\"3702\" data-start=\"3619\"\u003e \u003c\/p\u003e\n\u003ch2 data-end=\"3747\" data-start=\"3709\"\u003e\u003cstrong data-end=\"3747\" data-start=\"3712\"\u003eResearch Context Considerations\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cul data-end=\"3954\" data-start=\"3748\"\u003e\n\u003cli data-end=\"3793\" data-start=\"3748\"\u003e\n\u003cp data-end=\"3793\" data-start=\"3750\"\u003eEffects are \u003cstrong data-end=\"3793\" data-start=\"3762\"\u003edose- and context-dependent\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3850\" data-start=\"3794\"\u003e\n\u003cp data-end=\"3850\" data-start=\"3796\"\u003eBehavioral outcomes vary by species and baseline state\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3899\" data-start=\"3851\"\u003e\n\u003cp data-end=\"3899\" data-start=\"3853\"\u003eCircadian timing influences response magnitude\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3954\" data-start=\"3900\"\u003e\n\u003cp data-end=\"3954\" data-start=\"3902\"\u003eMC4R-deficient models show blunted or absent effects\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2 data-end=\"3990\" data-start=\"3961\"\u003e\u003cstrong data-end=\"3990\" data-start=\"3964\"\u003eProduct Specifications\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cul data-end=\"4385\" data-start=\"3992\"\u003e\n\u003cli data-end=\"4037\" data-start=\"3992\"\u003e\n\u003cp data-end=\"4037\" data-start=\"3994\"\u003e\u003cstrong data-end=\"4012\" data-start=\"3994\"\u003eCompound Name:\u003c\/strong\u003e PT-141 (Bremelanotide)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4073\" data-start=\"4038\"\u003e\n\u003cp data-end=\"4073\" data-start=\"4040\"\u003e\u003cstrong data-end=\"4055\" data-start=\"4040\"\u003eCAS Number:\u003c\/strong\u003e 1607799-13-2\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4117\" data-start=\"4074\"\u003e\n\u003cp data-end=\"4117\" data-start=\"4076\"\u003e\u003cstrong data-end=\"4098\" data-start=\"4076\"\u003eMolecular Formula:\u003c\/strong\u003e C₅₀H₆₈N₁₄O₁₀\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4157\" data-start=\"4118\"\u003e\n\u003cp data-end=\"4157\" data-start=\"4120\"\u003e\u003cstrong data-end=\"4141\" data-start=\"4120\"\u003eMolecular Weight:\u003c\/strong\u003e 1085.2 Da (acetate)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4210\" data-start=\"4158\"\u003e\n\u003cp data-end=\"4210\" data-start=\"4160\"\u003e\u003cstrong data-end=\"4178\" data-start=\"4160\"\u003ePeptide Class:\u003c\/strong\u003e Melanocortin receptor agonist\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4247\" data-start=\"4211\"\u003e\n\u003cp data-end=\"4247\" data-start=\"4213\"\u003e\u003cstrong data-end=\"4224\" data-start=\"4213\"\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4280\" data-start=\"4248\"\u003e\n\u003cp data-end=\"4280\" data-start=\"4250\"\u003e\u003cstrong data-end=\"4259\" data-start=\"4250\"\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4325\" data-start=\"4281\"\u003e\n\u003cp data-end=\"4325\" data-start=\"4283\"\u003e\u003cstrong data-end=\"4298\" data-start=\"4283\"\u003eAppearance:\u003c\/strong\u003e White to off-white solid\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4385\" data-start=\"4326\"\u003e\n\u003cp data-end=\"4385\" data-start=\"4328\"\u003e\u003cstrong data-end=\"4340\" data-start=\"4328\"\u003eStorage:\u003c\/strong\u003e ≤ –20 °C, desiccated, protected from light\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2 data-start=\"598\" data-end=\"638\"\u003e\u003cstrong data-start=\"598\" data-end=\"636\"\u003eBatch Documentation \u0026amp; Traceability\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"645\" data-end=\"762\"\u003eEach vial is shipped with a \u003cstrong data-start=\"673\" data-end=\"697\"\u003elot-specific QR code\u003c\/strong\u003e that provides secure access to batch documentation, including:\u003c\/p\u003e\n\u003cp data-start=\"769\" data-end=\"891\"\u003e• Certificate of Analysis (COA)\u003cbr data-start=\"800\" data-end=\"803\"\u003e• Identity verification report (HPLC \/ MS)\u003cbr data-start=\"847\" data-end=\"850\"\u003e• Lot number, potency, and expiration\u003c\/p\u003e\n\u003cp data-start=\"898\" data-end=\"1028\"\u003eDocumentation is \u003cstrong data-start=\"915\" data-end=\"955\"\u003elocked to the specific batch shipped\u003c\/strong\u003e to ensure traceability, version control, and research reproducibility.\u003c\/p\u003e\n\u003cp data-start=\"1035\" data-end=\"1113\"\u003eQR access is provided with the physical product and is not reused across lots.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2 data-end=\"4957\" data-start=\"4927\"\u003e\u003cstrong data-end=\"4957\" data-start=\"4930\"\u003eResearch Use Disclaimer\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-end=\"5127\" data-start=\"4958\"\u003eThis compound is supplied \u003cstrong data-end=\"5027\" data-start=\"4984\"\u003eexclusively for laboratory research use\u003c\/strong\u003e.\u003cbr data-end=\"5031\" data-start=\"5028\"\u003eNot for human or veterinary use.\u003cbr data-end=\"5066\" data-start=\"5063\"\u003eNot for diagnostic, therapeutic, or consumptive applications.\u003c\/p\u003e","brand":"Velora Biolabs","offers":[{"title":"10 mg vial","offer_id":47055873245338,"sku":"VBL-PT-RS-010","price":49.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0719\/1484\/8410\/files\/PT10.png?v=1782676421","url":"https:\/\/velorabiolabs.com\/products\/pt-141-peptide","provider":"Velora Biolabs","version":"1.0","type":"link"}