{"product_id":"mots-c-peptide","title":"MOTS-C Peptide | Metabolic Research","description":"\u003ch3 data-start=\"584\" data-end=\"679\"\u003eMitochondrial-Derived Peptide for Metabolic Signaling, Cellular Stress \u0026amp; Longevity Research\u003c\/h3\u003e\n\u003cp data-start=\"681\" data-end=\"831\"\u003e\u003cstrong data-start=\"681\" data-end=\"694\"\u003eCategory:\u003c\/strong\u003e\u003cbr data-start=\"694\" data-end=\"697\"\u003eMitochondrial \u0026amp; Metabolic Signaling • Longevity \u0026amp; Cellular Stress Response • Insulin \u0026amp; Energy Homeostasis\u003c\/p\u003e\n\u003cp data-start=\"681\" data-end=\"831\"\u003e \u003c\/p\u003e\n\u003ch2 data-start=\"838\" data-end=\"867\"\u003e\u003cstrong data-start=\"841\" data-end=\"867\"\u003eWhat Researchers Study\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"868\" data-end=\"1179\"\u003eMOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a \u003cstrong data-start=\"933\" data-end=\"966\"\u003emitochondrial-encoded peptide\u003c\/strong\u003e consisting of 16 amino acids. Unlike most signaling peptides encoded by nuclear DNA, MOTS-c originates from the \u003cstrong data-start=\"1079\" data-end=\"1103\"\u003emitochondrial genome\u003c\/strong\u003e and exerts effects on \u003cstrong data-start=\"1126\" data-end=\"1178\"\u003enuclear gene expression and metabolic regulation\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp data-start=\"1181\" data-end=\"1385\"\u003eResearchers study MOTS-c as a \u003cstrong data-start=\"1211\" data-end=\"1258\"\u003emitochondrial-to-nuclear signaling molecule\u003c\/strong\u003e, investigating how mitochondria communicate metabolic status, stress signals, and energy availability to the rest of the cell.\u003c\/p\u003e\n\u003cp data-start=\"1181\" data-end=\"1385\"\u003e \u003c\/p\u003e\n\u003ch2 data-start=\"1392\" data-end=\"1430\"\u003e\u003cstrong data-start=\"1395\" data-end=\"1430\"\u003ePrimary Signal Pathways Studied\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"1431\" data-end=\"1480\"\u003eResearch involving MOTS-c focuses on its role in:\u003c\/p\u003e\n\u003cul data-start=\"1482\" data-end=\"1950\"\u003e\n\u003cli data-start=\"1482\" data-end=\"1571\"\u003e\n\u003cp data-start=\"1484\" data-end=\"1571\"\u003e\u003cstrong data-start=\"1484\" data-end=\"1533\"\u003eAMP-activated protein kinase (AMPK) signaling\u003c\/strong\u003e, central to cellular energy sensing\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"1572\" data-end=\"1679\"\u003e\n\u003cp data-start=\"1574\" data-end=\"1679\"\u003e\u003cstrong data-start=\"1574\" data-end=\"1624\"\u003eGlucose and insulin-related metabolic pathways\u003c\/strong\u003e, linking mitochondrial function to nutrient handling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"1680\" data-end=\"1772\"\u003e\n\u003cp data-start=\"1682\" data-end=\"1772\"\u003e\u003cstrong data-start=\"1682\" data-end=\"1718\"\u003eMitochondrial–nuclear cross-talk\u003c\/strong\u003e, influencing gene expression under metabolic stress\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"1773\" data-end=\"1849\"\u003e\n\u003cp data-start=\"1775\" data-end=\"1849\"\u003e\u003cstrong data-start=\"1775\" data-end=\"1815\"\u003eOxidative stress response mechanisms\u003c\/strong\u003e, supporting cellular resilience\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"1850\" data-end=\"1950\"\u003e\n\u003cp data-start=\"1852\" data-end=\"1950\"\u003e\u003cstrong data-start=\"1852\" data-end=\"1891\"\u003eAge-associated metabolic regulation\u003c\/strong\u003e, particularly in muscle and metabolically active tissues\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"1952\" data-end=\"2058\"\u003eMOTS-c is notable for acting as a \u003cstrong data-start=\"1986\" data-end=\"2019\"\u003esystemic mitochondrial signal\u003c\/strong\u003e, rather than a receptor-bound hormone.\u003c\/p\u003e\n\u003cp data-start=\"1952\" data-end=\"2058\"\u003e \u003c\/p\u003e\n\u003ch2 data-start=\"2065\" data-end=\"2099\"\u003e\u003cstrong data-start=\"2068\" data-end=\"2099\"\u003eWhy This Peptide Is Studied\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"2100\" data-end=\"2301\"\u003eMitochondrial dysfunction is a core driver of metabolic disease, aging, and cellular stress intolerance. Many metabolic regulators act downstream of mitochondria, making causality difficult to isolate.\u003c\/p\u003e\n\u003cp data-start=\"2303\" data-end=\"2354\"\u003eMOTS-c is studied because it allows researchers to:\u003c\/p\u003e\n\u003cul data-start=\"2356\" data-end=\"2645\"\u003e\n\u003cli data-start=\"2356\" data-end=\"2417\"\u003e\n\u003cp data-start=\"2358\" data-end=\"2417\"\u003eExamine \u003cstrong data-start=\"2366\" data-end=\"2415\"\u003edirect mitochondrial signaling to the nucleus\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2418\" data-end=\"2493\"\u003e\n\u003cp data-start=\"2420\" data-end=\"2493\"\u003eInvestigate how mitochondria regulate \u003cstrong data-start=\"2458\" data-end=\"2491\"\u003ewhole-cell metabolic programs\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2494\" data-end=\"2578\"\u003e\n\u003cp data-start=\"2496\" data-end=\"2578\"\u003eExplore mechanisms linking \u003cstrong data-start=\"2523\" data-end=\"2576\"\u003eaging, insulin sensitivity, and energy metabolism\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2579\" data-end=\"2645\"\u003e\n\u003cp data-start=\"2581\" data-end=\"2645\"\u003eStudy adaptive responses to \u003cstrong data-start=\"2609\" data-end=\"2643\"\u003emetabolic and oxidative stress\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"2647\" data-end=\"2747\"\u003eThis positions MOTS-c as a central research tool in \u003cstrong data-start=\"2699\" data-end=\"2746\"\u003emitochondrial biology and longevity science\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp data-start=\"2647\" data-end=\"2747\"\u003e \u003c\/p\u003e\n\u003ch2 data-start=\"2754\" data-end=\"2787\"\u003e\u003cstrong data-start=\"2757\" data-end=\"2787\"\u003eResearch Areas of Interest\u003c\/strong\u003e\u003c\/h2\u003e\n\u003ch3 data-start=\"2789\" data-end=\"2835\"\u003e\u003cstrong data-start=\"2793\" data-end=\"2835\"\u003eMetabolic \u0026amp; Insulin Signaling Research\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-start=\"2836\" data-end=\"2933\"\u003eMOTS-c is widely studied in models of insulin resistance, glucose handling, and metabolic stress.\u003c\/p\u003e\n\u003ch3 data-start=\"2935\" data-end=\"2978\"\u003e\u003cstrong data-start=\"2939\" data-end=\"2978\"\u003eLongevity \u0026amp; Cellular Stress Biology\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-start=\"2979\" data-end=\"3099\"\u003eResearch explores how mitochondrial-derived peptides influence cellular aging, stress resistance, and metabolic decline.\u003c\/p\u003e\n\u003ch3 data-start=\"3101\" data-end=\"3145\"\u003e\u003cstrong data-start=\"3105\" data-end=\"3145\"\u003eMitochondrial Communication Pathways\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-start=\"3146\" data-end=\"3279\"\u003eMOTS-c is a key model compound for studying \u003cstrong data-start=\"3190\" data-end=\"3228\"\u003emitochondrial retrograde signaling\u003c\/strong\u003e—how mitochondria regulate nuclear gene expression.\u003c\/p\u003e\n\u003ch3 data-start=\"3281\" data-end=\"3333\"\u003e\u003cstrong data-start=\"3285\" data-end=\"3333\"\u003eNeuro-Metabolic \u0026amp; Systemic Energy Regulation\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-start=\"3334\" data-end=\"3444\"\u003eEmerging research investigates how mitochondrial signaling peptides affect tissues with high energetic demand.\u003c\/p\u003e\n\u003cp data-start=\"3334\" data-end=\"3444\"\u003e \u003c\/p\u003e\n\u003ch2 data-start=\"3451\" data-end=\"3488\"\u003e\u003cstrong data-start=\"3454\" data-end=\"3488\"\u003eSelected Scientific References\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cul data-start=\"3489\" data-end=\"3794\"\u003e\n\u003cli data-start=\"3489\" data-end=\"3583\"\u003e\n\u003cp data-start=\"3491\" data-end=\"3583\"\u003eLee et al., \u003cem data-start=\"3503\" data-end=\"3520\"\u003eCell Metabolism\u003c\/em\u003e — Discovery of MOTS-c and AMPK-mediated metabolic regulation\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3584\" data-end=\"3653\"\u003e\n\u003cp data-start=\"3586\" data-end=\"3653\"\u003eKim et al., \u003cem data-start=\"3598\" data-end=\"3610\"\u003eAging Cell\u003c\/em\u003e — MOTS-c and oxidative stress resistance\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3654\" data-end=\"3730\"\u003e\n\u003cp data-start=\"3656\" data-end=\"3730\"\u003eZempo et al., \u003cem data-start=\"3670\" data-end=\"3685\"\u003eFASEB Journal\u003c\/em\u003e — Mitochondrial-derived peptides and aging\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3731\" data-end=\"3794\"\u003e\n\u003cp data-start=\"3733\" data-end=\"3794\"\u003eReynolds et al., \u003cem data-start=\"3750\" data-end=\"3760\"\u003eDiabetes\u003c\/em\u003e — MOTS-c and glucose metabolism\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"3796\" data-end=\"3868\"\u003e(References provided for educational context and literature navigation.)\u003c\/p\u003e\n\u003cp data-start=\"3796\" data-end=\"3868\"\u003e \u003c\/p\u003e\n\u003ch2 data-start=\"3875\" data-end=\"3904\"\u003e\u003cstrong data-start=\"3878\" data-end=\"3904\"\u003eProduct Specifications\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cul data-start=\"3906\" data-end=\"4378\"\u003e\n\u003cli data-start=\"3906\" data-end=\"3984\"\u003e\n\u003cp data-start=\"3908\" data-end=\"3984\"\u003e\u003cstrong data-start=\"3908\" data-end=\"3926\"\u003eCompound Name:\u003c\/strong\u003e MOTS-c (Mitochondrial Open Reading Frame of 12S rRNA-c)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3985\" data-end=\"4012\"\u003e\n\u003cp data-start=\"3987\" data-end=\"4012\"\u003e\u003cstrong data-start=\"3987\" data-end=\"4002\"\u003eCAS Number:\u003c\/strong\u003e 1627580-64-6\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4013\" data-end=\"4074\"\u003e\n\u003cp data-start=\"4015\" data-end=\"4074\"\u003e\u003cstrong data-start=\"4015\" data-end=\"4037\"\u003eMolecular Formula:\u003c\/strong\u003e C₁₀₁H₁₅₂N₂₈O₂₂S₂\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4075\" data-end=\"4167\"\u003e\n\u003cp data-start=\"4077\" data-end=\"4167\"\u003e\u003cstrong data-start=\"4077\" data-end=\"4101\"\u003eAmino Acid Sequence:\u003c\/strong\u003e  Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4168\" data-end=\"4203\"\u003e\n\u003cp data-start=\"4170\" data-end=\"4203\"\u003e\u003cstrong data-start=\"4170\" data-end=\"4191\"\u003eMolecular Weight:\u003c\/strong\u003e 2,174.6 Da\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4204\" data-end=\"4240\"\u003e\n\u003cp data-start=\"4206\" data-end=\"4240\"\u003e\u003cstrong data-start=\"4206\" data-end=\"4217\"\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4241\" data-end=\"4273\"\u003e\n\u003cp data-start=\"4243\" data-end=\"4273\"\u003e\u003cstrong data-start=\"4243\" data-end=\"4252\"\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4274\" data-end=\"4318\"\u003e\n\u003cp data-start=\"4276\" data-end=\"4318\"\u003e\u003cstrong data-start=\"4276\" data-end=\"4291\"\u003eAppearance:\u003c\/strong\u003e White to off-white solid\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4319\" data-end=\"4378\"\u003e\n\u003cp data-start=\"4321\" data-end=\"4378\"\u003e\u003cstrong data-start=\"4321\" data-end=\"4333\"\u003eStorage:\u003c\/strong\u003e ≤ –20 °C, desiccated, protected from light\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2 data-start=\"598\" data-end=\"638\"\u003e\u003cstrong data-start=\"598\" data-end=\"636\"\u003eBatch Documentation \u0026amp; Traceability\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"645\" data-end=\"762\"\u003eEach vial is shipped with a \u003cstrong data-start=\"673\" data-end=\"697\"\u003elot-specific QR code\u003c\/strong\u003e that provides secure access to batch documentation, including:\u003c\/p\u003e\n\u003cp data-start=\"769\" data-end=\"891\"\u003e• Certificate of Analysis (COA)\u003cbr data-start=\"800\" data-end=\"803\"\u003e• Identity verification report (HPLC \/ MS)\u003cbr data-start=\"847\" data-end=\"850\"\u003e• Lot number, potency, and expiration\u003c\/p\u003e\n\u003cp data-start=\"898\" data-end=\"1028\"\u003eDocumentation is \u003cstrong data-start=\"915\" data-end=\"955\"\u003elocked to the specific batch shipped\u003c\/strong\u003e to ensure traceability, version control, and research reproducibility.\u003c\/p\u003e\n\u003cp data-start=\"1035\" data-end=\"1113\"\u003eQR access is provided with the physical product and is not reused across lots.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2 data-start=\"4385\" data-end=\"4415\"\u003e\u003cstrong data-start=\"4388\" data-end=\"4415\"\u003eResearch Use Disclaimer\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"4416\" data-end=\"4629\"\u003eThis product is supplied strictly for \u003cstrong data-start=\"4454\" data-end=\"4519\"\u003elaboratory research and in-vitro or preclinical investigation\u003c\/strong\u003e.\u003cbr data-start=\"4520\" data-end=\"4523\"\u003eNot for human or veterinary use.\u003cbr data-start=\"4555\" data-end=\"4558\"\u003eNot for diagnostic, therapeutic, cosmetic, or consumptive applications.\u003c\/p\u003e","brand":"Velora Biolabs","offers":[{"title":"10 mg vial","offer_id":47055867773082,"sku":"VBL-MS-RS-010","price":79.0,"currency_code":"USD","in_stock":true},{"title":"40 mg vial","offer_id":47055868100762,"sku":"VBL-MS-RS-040","price":129.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0719\/1484\/8410\/files\/MS40.png?v=1782680504","url":"https:\/\/velorabiolabs.com\/products\/mots-c-peptide","provider":"Velora Biolabs","version":"1.0","type":"link"}