{"product_id":"foxo4-dri-peptide","title":"FOXO4-DRI Peptide | Senolytic Research","description":"\u003ch3 data-start=\"430\" data-end=\"500\"\u003ePeptide Inhibitor for Cellular Senescence \u0026amp; Aging Pathway Research\u003c\/h3\u003e\n\u003cp data-start=\"502\" data-end=\"628\"\u003e\u003cstrong data-start=\"502\" data-end=\"515\"\u003eCategory:\u003c\/strong\u003e\u003cbr data-start=\"515\" data-end=\"518\"\u003eLongevity \u0026amp; Cellular Senescence • Apoptosis \u0026amp; DNA Damage Response • Aging Biology\u003c\/p\u003e\n\u003cp data-start=\"502\" data-end=\"628\"\u003e \u003c\/p\u003e\n\u003ch2 data-start=\"635\" data-end=\"664\"\u003e\u003cstrong data-start=\"638\" data-end=\"664\"\u003eWhat Researchers Study\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"665\" data-end=\"1030\"\u003eFOXO4-DRI is a synthetic peptide designed to disrupt the interaction between \u003cstrong data-start=\"742\" data-end=\"769\"\u003eFOXO4 (Forkhead box O4)\u003c\/strong\u003e and \u003cstrong data-start=\"774\" data-end=\"781\"\u003ep53\u003c\/strong\u003e, a key protein involved in cell cycle regulation and apoptosis. Researchers study FOXO4-DRI as a \u003cstrong data-start=\"879\" data-end=\"899\"\u003emechanistic tool\u003c\/strong\u003e for investigating \u003cstrong data-start=\"918\" data-end=\"941\"\u003ecellular senescence\u003c\/strong\u003e, a state in which damaged or aged cells cease dividing but resist programmed cell death.\u003c\/p\u003e\n\u003cp data-start=\"1032\" data-end=\"1207\"\u003eIn laboratory and preclinical models, FOXO4-DRI is used to explore how selectively targeting senescent cells affects tissue function, aging pathways, and cellular homeostasis.\u003c\/p\u003e\n\u003cp data-start=\"1032\" data-end=\"1207\"\u003e \u003c\/p\u003e\n\u003ch2 data-start=\"1214\" data-end=\"1252\"\u003e\u003cstrong data-start=\"1217\" data-end=\"1252\"\u003ePrimary Signal Pathways Studied\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"1253\" data-end=\"1314\"\u003eResearch involving FOXO4-DRI focuses on its influence within:\u003c\/p\u003e\n\u003cul data-start=\"1316\" data-end=\"1659\"\u003e\n\u003cli data-start=\"1316\" data-end=\"1400\"\u003e\n\u003cp data-start=\"1318\" data-end=\"1400\"\u003e\u003cstrong data-start=\"1318\" data-end=\"1357\"\u003eFOXO transcription factor signaling\u003c\/strong\u003e, particularly FOXO4–p53 binding dynamics\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"1401\" data-end=\"1472\"\u003e\n\u003cp data-start=\"1403\" data-end=\"1472\"\u003e\u003cstrong data-start=\"1403\" data-end=\"1438\"\u003ep53-mediated apoptosis pathways\u003c\/strong\u003e, central to DNA damage response\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"1473\" data-end=\"1567\"\u003e\n\u003cp data-start=\"1475\" data-end=\"1567\"\u003e\u003cstrong data-start=\"1475\" data-end=\"1521\"\u003eCellular senescence maintenance mechanisms\u003c\/strong\u003e, including survival signaling in aged cells\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"1568\" data-end=\"1659\"\u003e\n\u003cp data-start=\"1570\" data-end=\"1659\"\u003e\u003cstrong data-start=\"1570\" data-end=\"1614\"\u003eDNA damage and stress-response signaling\u003c\/strong\u003e, relevant to aging and degenerative models\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"1661\" data-end=\"1810\"\u003eFOXO4-DRI is notable for its \u003cstrong data-start=\"1690\" data-end=\"1712\"\u003etargeted mechanism\u003c\/strong\u003e, acting on protein–protein interactions rather than broadly altering transcription or metabolism.\u003c\/p\u003e\n\u003cp data-start=\"1661\" data-end=\"1810\"\u003e \u003c\/p\u003e\n\u003ch2 data-start=\"1817\" data-end=\"1851\"\u003e\u003cstrong data-start=\"1820\" data-end=\"1851\"\u003eWhy This Peptide Is Studied\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"1852\" data-end=\"2064\"\u003eSenescent cells accumulate with age and contribute to tissue dysfunction through inflammatory signaling and impaired regeneration. Many senolytic strategies act broadly, increasing the risk of off-target effects.\u003c\/p\u003e\n\u003cp data-start=\"2066\" data-end=\"2120\"\u003eFOXO4-DRI is studied because it allows researchers to:\u003c\/p\u003e\n\u003cul data-start=\"2122\" data-end=\"2345\"\u003e\n\u003cli data-start=\"2122\" data-end=\"2180\"\u003e\n\u003cp data-start=\"2124\" data-end=\"2180\"\u003eExamine \u003cstrong data-start=\"2132\" data-end=\"2178\"\u003eselective vulnerability of senescent cells\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2181\" data-end=\"2272\"\u003e\n\u003cp data-start=\"2183\" data-end=\"2272\"\u003eExplore how disrupting survival signaling triggers apoptosis specifically in aged cells\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2273\" data-end=\"2345\"\u003e\n\u003cp data-start=\"2275\" data-end=\"2345\"\u003eInvestigate links between senescence clearance and tissue resilience\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"2347\" data-end=\"2479\"\u003eThis makes FOXO4-DRI a critical research tool in \u003cstrong data-start=\"2396\" data-end=\"2413\"\u003eaging biology\u003c\/strong\u003e, \u003cstrong data-start=\"2415\" data-end=\"2438\"\u003esenescence modeling\u003c\/strong\u003e, and \u003cstrong data-start=\"2444\" data-end=\"2478\"\u003emechanistic longevity research\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp data-start=\"2347\" data-end=\"2479\"\u003e \u003c\/p\u003e\n\u003ch2 data-start=\"2486\" data-end=\"2519\"\u003e\u003cstrong data-start=\"2489\" data-end=\"2519\"\u003eResearch Areas of Interest\u003c\/strong\u003e\u003c\/h2\u003e\n\u003ch3 data-start=\"2521\" data-end=\"2565\"\u003e\u003cstrong data-start=\"2525\" data-end=\"2565\"\u003eCellular Senescence \u0026amp; Aging Research\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-start=\"2566\" data-end=\"2690\"\u003eFOXO4-DRI is widely studied in models evaluating senescent cell burden, lifespan markers, and age-associated tissue decline.\u003c\/p\u003e\n\u003ch3 data-start=\"2692\" data-end=\"2736\"\u003e\u003cstrong data-start=\"2696\" data-end=\"2736\"\u003eDNA Damage \u0026amp; Stress-Response Biology\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-start=\"2737\" data-end=\"2854\"\u003eResearch examines how FOXO4-p53 interactions regulate cell survival following chronic DNA damage or oxidative stress.\u003c\/p\u003e\n\u003ch3 data-start=\"2856\" data-end=\"2904\"\u003e\u003cstrong data-start=\"2860\" data-end=\"2904\"\u003eRegenerative \u0026amp; Tissue-Resilience Studies\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-start=\"2905\" data-end=\"3030\"\u003eExploratory work investigates how removal or modulation of senescent cells affects regenerative capacity and tissue function.\u003c\/p\u003e\n\u003cp data-start=\"2905\" data-end=\"3030\"\u003e \u003c\/p\u003e\n\u003ch2 data-start=\"3037\" data-end=\"3074\"\u003e\u003cstrong data-start=\"3040\" data-end=\"3074\"\u003eSelected Scientific References\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cul data-start=\"3075\" data-end=\"3366\"\u003e\n\u003cli data-start=\"3075\" data-end=\"3163\"\u003e\n\u003cp data-start=\"3077\" data-end=\"3163\"\u003eBaar et al., \u003cem data-start=\"3090\" data-end=\"3096\"\u003eCell\u003c\/em\u003e — Targeted apoptosis of senescent cells via FOXO4-p53 disruption\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3164\" data-end=\"3270\"\u003e\n\u003cp data-start=\"3166\" data-end=\"3270\"\u003eVan Deursen et al., \u003cem data-start=\"3186\" data-end=\"3225\"\u003eNature Reviews Molecular Cell Biology\u003c\/em\u003e — Cellular senescence in aging and disease\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3271\" data-end=\"3366\"\u003e\n\u003cp data-start=\"3273\" data-end=\"3366\"\u003eCampisi et al., \u003cem data-start=\"3289\" data-end=\"3318\"\u003eAnnual Review of Physiology\u003c\/em\u003e — Senescence signaling and tissue dysfunction\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"3368\" data-end=\"3440\"\u003e(References provided for educational context and literature navigation.)\u003c\/p\u003e\n\u003cp data-start=\"3368\" data-end=\"3440\"\u003e \u003c\/p\u003e\n\u003ch2 data-start=\"3447\" data-end=\"3476\"\u003e\u003cstrong data-start=\"3450\" data-end=\"3476\"\u003eProduct Specifications\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cul data-start=\"3478\" data-end=\"4025\"\u003e\n\u003cli data-start=\"3478\" data-end=\"3541\"\u003e\n\u003cp data-start=\"3480\" data-end=\"3541\"\u003e\u003cstrong data-start=\"3480\" data-end=\"3498\"\u003eCompound Name:\u003c\/strong\u003e FOXO4-DRI \u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3478\" data-end=\"3541\"\u003e\n\u003cp data-start=\"3480\" data-end=\"3541\"\u003e\u003cstrong data-start=\"3544\" data-end=\"3559\"\u003eCAS Number:\u003c\/strong\u003e 2460055-10-9\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3570\" data-end=\"3662\"\u003e\n\u003cp data-start=\"3572\" data-end=\"3662\"\u003e\u003cstrong data-start=\"3572\" data-end=\"3594\"\u003eMolecular Formula:\u003c\/strong\u003e C₂₂₈H₃₈₈N₈₆O₆₄\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3663\" data-end=\"3754\"\u003e\n\u003cp data-start=\"3665\" data-end=\"3754\"\u003e\u003cstrong data-start=\"3665\" data-end=\"3689\"\u003eAmino Acid Sequence:\u003c\/strong\u003e                                                                                              \u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eLeu-Thr-Leu-Arg-Lys-Glu-Pro-Ala-Ser-Glu-Ile-Ala-Gln-Ser-Ile-Leu-Glu-Ala-Tyr-Ser-Gln-Asn-Gly-Trp-Ala-Asn-Arg-Arg-Ser-Gly-Gly-Lys-Arg-Pro-Pro-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3755\" data-end=\"3850\"\u003e\n\u003cp data-start=\"3757\" data-end=\"3850\"\u003e\u003cstrong data-start=\"3757\" data-end=\"3778\"\u003eMolecular Weight:\u003c\/strong\u003e 5358.15\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3851\" data-end=\"3887\"\u003e\n\u003cp data-start=\"3853\" data-end=\"3887\"\u003e\u003cstrong data-start=\"3853\" data-end=\"3864\"\u003ePurity:\u003c\/strong\u003e ≥98% (HPLC verified)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3888\" data-end=\"3920\"\u003e\n\u003cp data-start=\"3890\" data-end=\"3920\"\u003e\u003cstrong data-start=\"3890\" data-end=\"3899\"\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3921\" data-end=\"3965\"\u003e\n\u003cp data-start=\"3923\" data-end=\"3965\"\u003e\u003cstrong data-start=\"3923\" data-end=\"3938\"\u003eAppearance:\u003c\/strong\u003e White to off-white solid\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3966\" data-end=\"4025\"\u003e\n\u003cp data-start=\"3968\" data-end=\"4025\"\u003e\u003cstrong data-start=\"3968\" data-end=\"3980\"\u003eStorage:\u003c\/strong\u003e ≤ –20 °C, desiccated, protected from light\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2 data-end=\"638\" data-start=\"598\"\u003e\u003cstrong data-end=\"636\" data-start=\"598\"\u003eBatch Documentation \u0026amp; Traceability\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-end=\"762\" data-start=\"645\"\u003eEach vial is shipped with a \u003cstrong data-end=\"697\" data-start=\"673\"\u003elot-specific QR code\u003c\/strong\u003e that provides secure access to batch documentation, including:\u003c\/p\u003e\n\u003cp data-end=\"891\" data-start=\"769\"\u003e• Certificate of Analysis (COA)\u003cbr data-end=\"803\" data-start=\"800\"\u003e• Identity verification report (HPLC \/ MS)\u003cbr data-end=\"850\" data-start=\"847\"\u003e• Lot number, potency, and expiration\u003c\/p\u003e\n\u003cp data-end=\"1028\" data-start=\"898\"\u003eDocumentation is \u003cstrong data-end=\"955\" data-start=\"915\"\u003elocked to the specific batch shipped\u003c\/strong\u003e to ensure traceability, version control, and research reproducibility.\u003c\/p\u003e\n\u003cp data-end=\"1113\" data-start=\"1035\"\u003eQR access is provided with the physical product and is not reused across lots.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2 data-start=\"4032\" data-end=\"4062\"\u003e\u003cstrong data-start=\"4035\" data-end=\"4062\"\u003eResearch Use Disclaimer\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"4063\" data-end=\"4266\"\u003eThis product is supplied strictly for \u003cstrong data-start=\"4101\" data-end=\"4166\"\u003elaboratory research and in-vitro or preclinical investigation\u003c\/strong\u003e.\u003cbr data-start=\"4167\" data-end=\"4170\"\u003eNot for human or veterinary use.\u003cbr data-start=\"4202\" data-end=\"4205\"\u003eNot for diagnostic, therapeutic, or consumptive applications.\u003c\/p\u003e","brand":"Velora Biolabs","offers":[{"title":"10 mg vial","offer_id":47055839559834,"sku":"VBL-FDX-RS-010","price":119.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0719\/1484\/8410\/files\/FX10.png?v=1782675348","url":"https:\/\/velorabiolabs.com\/products\/foxo4-dri-peptide","provider":"Velora Biolabs","version":"1.0","type":"link"}